The basic approach to bone tissue engineering involves the development of highly porous biodegradable 3D-scaffolds, with interconnected pore network structure for cellular in-growth, revascularization, adequate nutrition and oxygen supply. Electrospinning is a simple and cost-effective technique that enables to fabricate scaffolds, from both synthetic and natural polymers, mimicking the three-dimensional nano-scaled features of ECM1. Synthetic bioresorbable polymers provide structural functionalities to the scaffold; on the other hand, natural polymers display unique bioactive properties and excellent cellular affinity2. To combine natural and synthetic polymers, electrospinning of blends has been proposed as a useful strategy, such as in the case of polylactic acid and gelatin3-5. In the current work a different strategy named concomitantly electrospinning (co-electrospinning ) is presented. Nanofibrous scaffolds made up of poly(L)lactic acid (PLLA) fibers and Type A Gelatin (Gel) fibers were fabricated by co-electrospinning with the aim of combining the bioactivity of gelatin together with the structural stability of PLLA in a unique scaffold.

Biomimetic Gelatin/Poly(L-lactic acid) Composite Scaffolds by Co-Electrospinning / A. Fiorani; M. Gioffrè; C. Gualandi; M. L. Focarete; S. Panzavolta; B. Bracci; A. Bigi; P. Torricelli. - STAMPA. - (2012), pp. 22-22. (Intervento presentato al convegno Congresso Nazionale della Società Italiana di Biomateriali - SIB 2012 tenutosi a Lecce (italy) nel 18-20 giugno 2012).

Biomimetic Gelatin/Poly(L-lactic acid) Composite Scaffolds by Co-Electrospinning

FIORANI, ANDREA;GUALANDI, CHIARA;FOCARETE, MARIA LETIZIA;PANZAVOLTA, SILVIA;BRACCI, BARBARA;BIGI, ADRIANA;
2012

Abstract

The basic approach to bone tissue engineering involves the development of highly porous biodegradable 3D-scaffolds, with interconnected pore network structure for cellular in-growth, revascularization, adequate nutrition and oxygen supply. Electrospinning is a simple and cost-effective technique that enables to fabricate scaffolds, from both synthetic and natural polymers, mimicking the three-dimensional nano-scaled features of ECM1. Synthetic bioresorbable polymers provide structural functionalities to the scaffold; on the other hand, natural polymers display unique bioactive properties and excellent cellular affinity2. To combine natural and synthetic polymers, electrospinning of blends has been proposed as a useful strategy, such as in the case of polylactic acid and gelatin3-5. In the current work a different strategy named concomitantly electrospinning (co-electrospinning ) is presented. Nanofibrous scaffolds made up of poly(L)lactic acid (PLLA) fibers and Type A Gelatin (Gel) fibers were fabricated by co-electrospinning with the aim of combining the bioactivity of gelatin together with the structural stability of PLLA in a unique scaffold.
2012
Atti del Congresso Nazionale Biomateriali
22
22
Biomimetic Gelatin/Poly(L-lactic acid) Composite Scaffolds by Co-Electrospinning / A. Fiorani; M. Gioffrè; C. Gualandi; M. L. Focarete; S. Panzavolta; B. Bracci; A. Bigi; P. Torricelli. - STAMPA. - (2012), pp. 22-22. (Intervento presentato al convegno Congresso Nazionale della Società Italiana di Biomateriali - SIB 2012 tenutosi a Lecce (italy) nel 18-20 giugno 2012).
A. Fiorani; M. Gioffrè; C. Gualandi; M. L. Focarete; S. Panzavolta; B. Bracci; A. Bigi; P. Torricelli
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/130540
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