Background: Recent studies on the natural history of Hashimoto’s thyroiditis (HT) showed that in many patients thyroid function recovers over the years. Moreover the criteria to start a treatment with l-thyroxine has changed (TSH > 10 TAGfontoffTAGsymfontmTAGfontoffTAGstdfontU/ml). Objective and hypotheses: To verify after discontinuation of treatment, how many patients needed to resume it, based on the TSH and fT4 levels. Population and methods: We evaluated 51 children and adolescents(9 m e 42 f) affected with HT and in treatment with l-thyroxine for at least 1 year, who were examined in 5 italian Centres of Paediatric Endocrinology. TSH and fT4 serum level were assayed at baseline and after 2, 6 and 12 months. Treatment with l-thyroxine was restarted when TSH raised above 20 μU/ml and/or fT4 was below the normal range, while the patients were followed-up when TSH levels were between 10 and 20 μU/ml and fT4 was inn the normal range. Preliminary results: at baseline TSH was in the normal range in all 51 patients; treatment was restarted after 2 months in 15/51 (29.4%) patients, after 6 months in 1/30 (3.3%) and after 12 months in 1/13 (7.7%) (see figure). Conclusion: from our preliminary data it seems that not all children affected with Hashimoto’s thyroiditis need a life-long therapy.
Do children with Hashimoto’s thyroiditis need a life-long treatment with l-thyroxine? / Bonassai M; Longhi S; Gastaldi R; Loche S; Guzzetti C; Cappa M;Scirè G; Tronconi G; Passoni A; Cassio A; Cesaretti G; Salerno C; Corrias A; Radetti G. - In: HORMONE RESEARCH IN PAEDIATRICS. - ISSN 1663-2818. - STAMPA. - 78(Suppl1):(2012), pp. 244-244. (Intervento presentato al convegno 51th Annual Meeting of ESPE tenutosi a Leipzig, Germany nel September 20-23, 2012).
Do children with Hashimoto’s thyroiditis need a life-long treatment with l-thyroxine?
CASSIO, ALESSANDRA;
2012
Abstract
Background: Recent studies on the natural history of Hashimoto’s thyroiditis (HT) showed that in many patients thyroid function recovers over the years. Moreover the criteria to start a treatment with l-thyroxine has changed (TSH > 10 TAGfontoffTAGsymfontmTAGfontoffTAGstdfontU/ml). Objective and hypotheses: To verify after discontinuation of treatment, how many patients needed to resume it, based on the TSH and fT4 levels. Population and methods: We evaluated 51 children and adolescents(9 m e 42 f) affected with HT and in treatment with l-thyroxine for at least 1 year, who were examined in 5 italian Centres of Paediatric Endocrinology. TSH and fT4 serum level were assayed at baseline and after 2, 6 and 12 months. Treatment with l-thyroxine was restarted when TSH raised above 20 μU/ml and/or fT4 was below the normal range, while the patients were followed-up when TSH levels were between 10 and 20 μU/ml and fT4 was inn the normal range. Preliminary results: at baseline TSH was in the normal range in all 51 patients; treatment was restarted after 2 months in 15/51 (29.4%) patients, after 6 months in 1/30 (3.3%) and after 12 months in 1/13 (7.7%) (see figure). Conclusion: from our preliminary data it seems that not all children affected with Hashimoto’s thyroiditis need a life-long therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
