The aim of this study is the analysis of the APD adaptation in three different mathematical models of human ventricular endocardial cell: Grandi-Bers (2010, GB [4]), Carro-Pueyo (2011, CP [5]) and O’Hara-Rudy (2011, ORd [6]). Simulation results in response to different stimulation protocols have been considered, with reference to experimental data available in literature. In order to investigate the different causes responsible for APD adaptation, state variables have been selectively restored to their steady state values right after CL changes. By comparing the results for each model, the ionic mechanisms most likely occurring in real cells can be identified.
E. Passini, S. Severi (2012). Computational analysis of rate adaptation mechanisms in human cardiac action potential. BOLOGNA : Patron.
Computational analysis of rate adaptation mechanisms in human cardiac action potential
PASSINI, ELISA;SEVERI, STEFANO
2012
Abstract
The aim of this study is the analysis of the APD adaptation in three different mathematical models of human ventricular endocardial cell: Grandi-Bers (2010, GB [4]), Carro-Pueyo (2011, CP [5]) and O’Hara-Rudy (2011, ORd [6]). Simulation results in response to different stimulation protocols have been considered, with reference to experimental data available in literature. In order to investigate the different causes responsible for APD adaptation, state variables have been selectively restored to their steady state values right after CL changes. By comparing the results for each model, the ionic mechanisms most likely occurring in real cells can be identified.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
