The aim of this study is the analysis of the APD adaptation in three different mathematical models of human ventricular endocardial cell: Grandi-Bers (2010, GB [4]), Carro-Pueyo (2011, CP [5]) and O’Hara-Rudy (2011, ORd [6]). Simulation results in response to different stimulation protocols have been considered, with reference to experimental data available in literature. In order to investigate the different causes responsible for APD adaptation, state variables have been selectively restored to their steady state values right after CL changes. By comparing the results for each model, the ionic mechanisms most likely occurring in real cells can be identified.

E. Passini, S. Severi (2012). Computational analysis of rate adaptation mechanisms in human cardiac action potential. BOLOGNA : Patron.

Computational analysis of rate adaptation mechanisms in human cardiac action potential

PASSINI, ELISA;SEVERI, STEFANO
2012

Abstract

The aim of this study is the analysis of the APD adaptation in three different mathematical models of human ventricular endocardial cell: Grandi-Bers (2010, GB [4]), Carro-Pueyo (2011, CP [5]) and O’Hara-Rudy (2011, ORd [6]). Simulation results in response to different stimulation protocols have been considered, with reference to experimental data available in literature. In order to investigate the different causes responsible for APD adaptation, state variables have been selectively restored to their steady state values right after CL changes. By comparing the results for each model, the ionic mechanisms most likely occurring in real cells can be identified.
2012
Congresso Nazionale di Bioingegneria 2012 Atti
287
288
E. Passini, S. Severi (2012). Computational analysis of rate adaptation mechanisms in human cardiac action potential. BOLOGNA : Patron.
E. Passini; S. Severi
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/125833
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact