Human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) offer a new in vitro model to study cardiac cell properties and develop and test drugs. Anyway tThe high times and costs of the induction and differentiation process make interesting the use of in silico models to understand the hiPS-CM electrophysiology and response to pharmacological tools. We developed a hiPSC-CM action potential (AP) model, based on a variety of published experimental data, reproducing the main features of ventricular-like hiPSC-CMs: spontaneous firing activity, AP morphology and response to common current blockers.
Computational modelling of human induced pluripotent stem cell derived cardiomyocytes
PACI, MICHELANGELO;SEVERI, STEFANO
2012
Abstract
Human induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) offer a new in vitro model to study cardiac cell properties and develop and test drugs. Anyway tThe high times and costs of the induction and differentiation process make interesting the use of in silico models to understand the hiPS-CM electrophysiology and response to pharmacological tools. We developed a hiPSC-CM action potential (AP) model, based on a variety of published experimental data, reproducing the main features of ventricular-like hiPSC-CMs: spontaneous firing activity, AP morphology and response to common current blockers.File in questo prodotto:
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