The n-6 or omega 6 series [i.e. arachidonic acid (AA)] and the n-3 or omega-3 polyunsaturated fatty acids (n-3 PUFA), and particularly the long chain highly unsaturated ones (LC PUFA) [i.e. eicosapentaenoic and docosahexaenoic acid (EPA and DHA)], are essential for humans and work sometimes in synergy and sometimes in competition. Today, their role has been recognized as not only mere caloric, but with effects in cell differentiation and communication through a deep modulation to the cell core involved in gene regulation. These effects occur in all the body systems and organs, but with different outcomes depending on local or systemic inputs. Therefore, during fetal and neonatal development, LC PUFA contribute to growth and evolution, while, during inflammation, they orchestrate various functions of cells. Many disease conditions develop from inflammation. Obesity and metabolic syndrome are two examples in which diet and the hormonal milieu may disrupt multiple cells with release of cytokines. In the case of chronic stimuli, body metabolism changes. LC PUFA again, prove to be a potent tool to reverse or enhance these changes. In this chapter we want to focus on the effects of n-3 PUFA with regard to brain development and obesity.
Forchielli ML, Walker WA. (2012). The role of omega-3 in the development of the brain and obesity.. NEW YORK : Nova Publishers.
The role of omega-3 in the development of the brain and obesity.
FORCHIELLI, MARIA LUISA;
2012
Abstract
The n-6 or omega 6 series [i.e. arachidonic acid (AA)] and the n-3 or omega-3 polyunsaturated fatty acids (n-3 PUFA), and particularly the long chain highly unsaturated ones (LC PUFA) [i.e. eicosapentaenoic and docosahexaenoic acid (EPA and DHA)], are essential for humans and work sometimes in synergy and sometimes in competition. Today, their role has been recognized as not only mere caloric, but with effects in cell differentiation and communication through a deep modulation to the cell core involved in gene regulation. These effects occur in all the body systems and organs, but with different outcomes depending on local or systemic inputs. Therefore, during fetal and neonatal development, LC PUFA contribute to growth and evolution, while, during inflammation, they orchestrate various functions of cells. Many disease conditions develop from inflammation. Obesity and metabolic syndrome are two examples in which diet and the hormonal milieu may disrupt multiple cells with release of cytokines. In the case of chronic stimuli, body metabolism changes. LC PUFA again, prove to be a potent tool to reverse or enhance these changes. In this chapter we want to focus on the effects of n-3 PUFA with regard to brain development and obesity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
