Background and aims: Gastroesophageal reflux (GER) is common in preterm infants. First-line treatment in this population should be conservative (milk thickening and body positioning), due to possible side-effects of the commonly used drugs: nevertheless, at present thickened formula are nutritionally inadequate for preterm infants. The aim of this study is to test the efficacy of an amylopectin-thickened formula specifically designed for preterm infants on GER by combined impedance and pH monitoring (pH-MII). Methods: Nineteen symptomatic preterm infants (GA < 32 weeks) at full enteral feeding (150 ml/kg/day) underwent a 24-hour pH-MII. During the study period, they received 8 meals: 4 of preterm formula (PF) and 4 of a new amylopectin-thickened preterm formula (TPF). Acid and non-acid GER indexes detected after PF and TPF meals were compared by Wilcoxon Signed Ranks Test. Results: All the infants completed the study period. After TPF meals, a trend to a lower number of acid GER detected by pH monitoring meals was recorded [median 20 (range, 1-42) vs 24 (range, 5-75) after PF meals, p =0.073]; total number of GER was also lower [median 49 (range, 2-84) vs 49 (range, 17-117), p =0.076]. No differences between TPF and PF in non-acid GER indexes were detected. Conclusions: Preliminary results of the present study show that a thickened formula specifically designed to satisfy nutritional needs of preterm infants may improve acid GER in this population, but has no effect on non-acid GER. Further data from a larger population are needed to confirm these results.

Effect of a thickened formula specifically designed for preterm infants on gastroesophageal reflux

MARIANI, ELISA;CORVAGLIA, LUIGI TOMMASO;LEGNANI, ELENA LARA;FERLINI, MARIANNA;ACETI, ARIANNA;FALDELLA, GIACOMO
2011

Abstract

Background and aims: Gastroesophageal reflux (GER) is common in preterm infants. First-line treatment in this population should be conservative (milk thickening and body positioning), due to possible side-effects of the commonly used drugs: nevertheless, at present thickened formula are nutritionally inadequate for preterm infants. The aim of this study is to test the efficacy of an amylopectin-thickened formula specifically designed for preterm infants on GER by combined impedance and pH monitoring (pH-MII). Methods: Nineteen symptomatic preterm infants (GA < 32 weeks) at full enteral feeding (150 ml/kg/day) underwent a 24-hour pH-MII. During the study period, they received 8 meals: 4 of preterm formula (PF) and 4 of a new amylopectin-thickened preterm formula (TPF). Acid and non-acid GER indexes detected after PF and TPF meals were compared by Wilcoxon Signed Ranks Test. Results: All the infants completed the study period. After TPF meals, a trend to a lower number of acid GER detected by pH monitoring meals was recorded [median 20 (range, 1-42) vs 24 (range, 5-75) after PF meals, p =0.073]; total number of GER was also lower [median 49 (range, 2-84) vs 49 (range, 17-117), p =0.076]. No differences between TPF and PF in non-acid GER indexes were detected. Conclusions: Preliminary results of the present study show that a thickened formula specifically designed to satisfy nutritional needs of preterm infants may improve acid GER in this population, but has no effect on non-acid GER. Further data from a larger population are needed to confirm these results.
Pediatric Research (supplement 5s)
784
784
PEDIATRIC RESEARCH
E. Mariani; L. Corvaglia; E. Legnani; M. Ferlini; A. Aceti; G. Faldella
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/121132
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