Background and aims: Apnoea of prematurity (AOP) is a frequent clinical issue in the management of preterm infants; its relationship with gastroesophageal reflux (GER) is widely debated. In a previous study we highlighted an increase of the frequency of AOP after GER (GER-induced AOP). The aim of the present study is to evaluate the effect of an amylopectin-thickened formula specifically designed for preterm infants on AOP and on GER-induced AOP. Materials and Methods: Eighteen preterm infants (gestational age < 32 weeks) with recurrent apnoeas underwent a six-hours simultaneous and synchronized recording of polysomnography and pH-impedance monitoring (pH-MII). Each oral/nasal flow cessation lasting at least 5 seconds was considered as apnoea. Apnoeas detected within 30 seconds after the onset of GER were defined as GER-induced. Each patient received 2 meals, one of preterm formula (PF) and the other of a thickened formula specifically designed to satisfy preterm infants' nutritional needs (TPF). AOP and GER-induced AOP detected after PF and TPF meals were compared. Results: One-hundred-twenty-seven apnoeas were recorded after TPF (mean 5/patient, range 0-21), whereas 118 apnoeas were recorded after PF (mean 4.5, range 0-27). A lower number of GER-induced AOP was detected after TPF meals (3 vs 7 after PF meals). Conclusions: Preliminary results of the present study show that a thickened formula specifically designed for preterm infants is ineffective in reducing the total number of AOP, while it could be beneficial on GER-induced AOP. Further data from a larger population are needed to confirm these results.
M. Spizzichino, L. Corvaglia, D. Zama, B. Battistini, E. Legnani, G. Faldella (2011). Effect of a thickened formula specifically designed for preterm infants on apnoeas induced by gastroesophageal reflux. New York : NATURE PUBLISHING GROUP [10.1038/pr.2011.1010].
Effect of a thickened formula specifically designed for preterm infants on apnoeas induced by gastroesophageal reflux
CORVAGLIA, LUIGI TOMMASO;ZAMA, DANIELE;BATTISTINI, BARBARA;FALDELLA, GIACOMO
2011
Abstract
Background and aims: Apnoea of prematurity (AOP) is a frequent clinical issue in the management of preterm infants; its relationship with gastroesophageal reflux (GER) is widely debated. In a previous study we highlighted an increase of the frequency of AOP after GER (GER-induced AOP). The aim of the present study is to evaluate the effect of an amylopectin-thickened formula specifically designed for preterm infants on AOP and on GER-induced AOP. Materials and Methods: Eighteen preterm infants (gestational age < 32 weeks) with recurrent apnoeas underwent a six-hours simultaneous and synchronized recording of polysomnography and pH-impedance monitoring (pH-MII). Each oral/nasal flow cessation lasting at least 5 seconds was considered as apnoea. Apnoeas detected within 30 seconds after the onset of GER were defined as GER-induced. Each patient received 2 meals, one of preterm formula (PF) and the other of a thickened formula specifically designed to satisfy preterm infants' nutritional needs (TPF). AOP and GER-induced AOP detected after PF and TPF meals were compared. Results: One-hundred-twenty-seven apnoeas were recorded after TPF (mean 5/patient, range 0-21), whereas 118 apnoeas were recorded after PF (mean 4.5, range 0-27). A lower number of GER-induced AOP was detected after TPF meals (3 vs 7 after PF meals). Conclusions: Preliminary results of the present study show that a thickened formula specifically designed for preterm infants is ineffective in reducing the total number of AOP, while it could be beneficial on GER-induced AOP. Further data from a larger population are needed to confirm these results.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
