Feline oral squamous cell carcinoma (SCC) is a loco-regional disease harboring a poor prognosis in most cases. The complex anatomic location prevents from aggressive and wide surgical resection and tumors recur within weeks to few months. Response to chemotherapy and local control after radiation therapy has been disappointing. In this study, a multimodal approach including medical treatment, radiation therapy and surgery was attempted in 6 cats. Treatment was well tolerated. Three cats with sublingual SCC were alive and in complete remission at data analysis closure after 533, 231 and 136 days. One cat with laryngeal SCC died of renal lymphoma after 51 days; one cat with maxillary SCC died of a primary lung tumor 82 days after diagnosis. Only one cat developed metastases after 144 days. These encouraging preliminary results merit further evaluation in future clinical trials.
MARCONATO L., BUCHHOLZ J., VALENTI P., KASER-HOTZ B., KELLER M., BETTINI G. (2012). MULTIMODAL THERAPEUTIC APPROACH AND INTERDISCIPLINARY CHALLENGE FOR THE TREATMENT OF UNRESECTABLE ORAL SQUAMOUS CELL CARCINOMA IN 6 CATS: A PILOT STUDY. s.l : ESVONC - VCS.
MULTIMODAL THERAPEUTIC APPROACH AND INTERDISCIPLINARY CHALLENGE FOR THE TREATMENT OF UNRESECTABLE ORAL SQUAMOUS CELL CARCINOMA IN 6 CATS: A PILOT STUDY
MARCONATO L.;BETTINI, GIULIANO
2012
Abstract
Feline oral squamous cell carcinoma (SCC) is a loco-regional disease harboring a poor prognosis in most cases. The complex anatomic location prevents from aggressive and wide surgical resection and tumors recur within weeks to few months. Response to chemotherapy and local control after radiation therapy has been disappointing. In this study, a multimodal approach including medical treatment, radiation therapy and surgery was attempted in 6 cats. Treatment was well tolerated. Three cats with sublingual SCC were alive and in complete remission at data analysis closure after 533, 231 and 136 days. One cat with laryngeal SCC died of renal lymphoma after 51 days; one cat with maxillary SCC died of a primary lung tumor 82 days after diagnosis. Only one cat developed metastases after 144 days. These encouraging preliminary results merit further evaluation in future clinical trials.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
