In this review, we give an overview of the proteomic investigations aimed at elucidating the impact of antidepressants treatment on brain at the molecular level. We discuss the animal models in which currently available treatments of mood disorders have been investigated by proteomic approaches, with a critical analysis of the main studies and a comparison of the methodologies used. The results are reviewed in the light of the putative mechanism of action of antidepressant therapies, and overall suggest an activation of long-term events downstream of the neurotransmitter signalling.
Carboni L., Piubelli C., Domenici E. (2011). Proteome effects of antidepressant medications.. NEW YORK : Springer [10.1007/978-1-4419-7197-5_15].
Proteome effects of antidepressant medications.
CARBONI, LUCIA;
2011
Abstract
In this review, we give an overview of the proteomic investigations aimed at elucidating the impact of antidepressants treatment on brain at the molecular level. We discuss the animal models in which currently available treatments of mood disorders have been investigated by proteomic approaches, with a critical analysis of the main studies and a comparison of the methodologies used. The results are reviewed in the light of the putative mechanism of action of antidepressant therapies, and overall suggest an activation of long-term events downstream of the neurotransmitter signalling.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
