The present invention relates to the use of annellated pyrrole compounds and in particular ML3000 (licofelone), salts or derivatives thereof, for cancer management, and in general to the use of a compound of Formula (I): wherein the variables have the meanings given in the present description, for the prevention and/or the treatment of neoplasia, in particular neoplasia selected from the group consisting of papilloma, carcinoma, adenoma, and adenocarcinoma, e.g. human hairway or colorectal carcinoma, preferably fast growing, multidrug resistant and/or COX-2 negative neoplasia. The invention further relates to pharmaceutical compositions for the aforesaid purposes, comprising annellated pyrrole compounds and in particular ML3000 (licofelone), optical isomers, salts or derivatives thereof, as well as to a method of treating and/or preventing neoplasia and/or restoring the ability to undergo apoptosis in a cell having lost the same. This treatment ameliorates, diminishes, actively treats reverses or prevents any disease related to insufficient apoptosis, in particular neoplasia, and it may be combined with irradiation, heating and treatment with a cytotoxic agent for preventive and/or curative purposes.

Annellated pyrrole compounds for cancer management

GUARNIERI, TIZIANA;TAVOLARI, SIMONA;
2008

Abstract

The present invention relates to the use of annellated pyrrole compounds and in particular ML3000 (licofelone), salts or derivatives thereof, for cancer management, and in general to the use of a compound of Formula (I): wherein the variables have the meanings given in the present description, for the prevention and/or the treatment of neoplasia, in particular neoplasia selected from the group consisting of papilloma, carcinoma, adenoma, and adenocarcinoma, e.g. human hairway or colorectal carcinoma, preferably fast growing, multidrug resistant and/or COX-2 negative neoplasia. The invention further relates to pharmaceutical compositions for the aforesaid purposes, comprising annellated pyrrole compounds and in particular ML3000 (licofelone), optical isomers, salts or derivatives thereof, as well as to a method of treating and/or preventing neoplasia and/or restoring the ability to undergo apoptosis in a cell having lost the same. This treatment ameliorates, diminishes, actively treats reverses or prevents any disease related to insufficient apoptosis, in particular neoplasia, and it may be combined with irradiation, heating and treatment with a cytotoxic agent for preventive and/or curative purposes.
WO2008/012110 A2
S. Laufer; T. Guarnieri; S. Tavolari; V. Tomasi; E. Palazzini; M. Barbanti
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/114813
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