Alcohol dehydrogenases are enzymes involved in natural oxidoreductive interconversions between alcohols and aldehydes. In particular Horse Liver Alcohol Dehydrogenase (HLADH) is an interesting enzyme and it has been used in several chemical processes. In a research project on the development of a chemoenzymatic synthesis of Profens we used HLADH for the asymmetric reduction of several racemic 2-arylpropanals to (2S)-arylpropanols. Optimized reaction conditions in a buffer–organic medium, allowed the occurrence of a dynamic kinetic resolution (DKR) process

ALCOHOL DEHYDROGENASES AND BIOACTIVE MOLECULES: AN APPLICATION IN THE SYNTHESIS OF PROFENS

GIACOMINI, DARIA;GALLETTI, PAOLA;PORI, MATTEO
2011

Abstract

Alcohol dehydrogenases are enzymes involved in natural oxidoreductive interconversions between alcohols and aldehydes. In particular Horse Liver Alcohol Dehydrogenase (HLADH) is an interesting enzyme and it has been used in several chemical processes. In a research project on the development of a chemoenzymatic synthesis of Profens we used HLADH for the asymmetric reduction of several racemic 2-arylpropanals to (2S)-arylpropanols. Optimized reaction conditions in a buffer–organic medium, allowed the occurrence of a dynamic kinetic resolution (DKR) process
Italian Industrial Biotech 2011, Milano
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Daria Giacomini; Paola Galletti; Matteo Pori
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/114091
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