A dental care product comprising carbonate- substituted strontium-hydroxyapatite particles having a lactoferrin-functionalized surface, wherein said particles have the formula: Ca(10-x) Srx (ΡO4)(6-γ) (CO3)y (OH)2 wherein x is a number comprised between 0.0010 and 0.015; and y is a number comprised between 0.0010 and 0.010; and wherein said carbonate-substituted strontium-hydroxyapatite particles have a crystallinity degree CD comprised between 55 and 85%. The carbonate-substituted strontium-hydroxyapatite particles are biomimetic for composition, structure and morphology allowing a strong chemical affinity with natural enamel and dentine hydroxyapatite crystals and inducing the formation of a rimineralizing and protective surface coating on enamel and dentine.

Dental care products containing biomimetics hydroxyapatiteparticles having a protein-functionalized surface

FOLTRAN, ISMAELA;FORESTI, ELISABETTA;LELLI, MARCO;MARCHETTI, MARCO;PIERINI, FILIPPO;ROVERI, NORBERTO;LESCI, ISIDORO GIORGIO
2011

Abstract

A dental care product comprising carbonate- substituted strontium-hydroxyapatite particles having a lactoferrin-functionalized surface, wherein said particles have the formula: Ca(10-x) Srx (ΡO4)(6-γ) (CO3)y (OH)2 wherein x is a number comprised between 0.0010 and 0.015; and y is a number comprised between 0.0010 and 0.010; and wherein said carbonate-substituted strontium-hydroxyapatite particles have a crystallinity degree CD comprised between 55 and 85%. The carbonate-substituted strontium-hydroxyapatite particles are biomimetic for composition, structure and morphology allowing a strong chemical affinity with natural enamel and dentine hydroxyapatite crystals and inducing the formation of a rimineralizing and protective surface coating on enamel and dentine.
PCT/EP2011/005601
I.Foltran; E. Foresti; M. Lelli; M. Marchetti; F. Pierini; N. Roveri; S. Vecchiotti; G. Montebugnoli; E. D’amen; I.G. Lesci
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/113814
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