Calcium phosphate cements (CPCs) are good candidates for bone regeneration, due to their good biocompatibility, bone integration and close similarity to the mineral component of bones. In this work we investigated the possibility to introduce biodegradable polymers, namely PLLA and PLGA, into the composition of a biomimetic cement. To this aim we introduced different amounts of PLLA and PLGA nanofibers produced by the electrospinning technique into a gelatin containing alfa-tricalcium phosphate (alfa-TCP) cement. Degradability, structure, morphology and mechanical properties of the cements were analyzed as a function of composition.
Incorporation of biodegradable electrospun fibers into calcium phosphate bone cement
PANZAVOLTA, SILVIA;BIGI, ADRIANA;BRACCI, BARBARA;FOCARETE, MARIA LETIZIA;GUALANDI, CHIARA
2011
Abstract
Calcium phosphate cements (CPCs) are good candidates for bone regeneration, due to their good biocompatibility, bone integration and close similarity to the mineral component of bones. In this work we investigated the possibility to introduce biodegradable polymers, namely PLLA and PLGA, into the composition of a biomimetic cement. To this aim we introduced different amounts of PLLA and PLGA nanofibers produced by the electrospinning technique into a gelatin containing alfa-tricalcium phosphate (alfa-TCP) cement. Degradability, structure, morphology and mechanical properties of the cements were analyzed as a function of composition.File in questo prodotto:
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