The development of synthetically bioengineered cardiac implants is believed to be an effective approach to restore impaired heart functions. One of the possibility is to develop a flexible patch sized to fit the infarcted area made out of a elastomeric biomaterial able to integrate with the surroundings and to promote cell functions. In this work a commercial random copolymer of (L)-lactic acid with trimethylene carbonate (P(L)LA-co-TMC) is used to fabricate a biomimetic electrospun scaffold and its potentialities for myocardial tissue engineering are investigated compared to poly(L)lactic acid (P(L)LA) electrospun scaffold.
Elastomeric electrospun scaffolds of poly(L-lactide-co-trimethylene carbonate) for myocardial tissue engineering
FOCARETE, MARIA LETIZIA;GUALANDI, CHIARA;
2011
Abstract
The development of synthetically bioengineered cardiac implants is believed to be an effective approach to restore impaired heart functions. One of the possibility is to develop a flexible patch sized to fit the infarcted area made out of a elastomeric biomaterial able to integrate with the surroundings and to promote cell functions. In this work a commercial random copolymer of (L)-lactic acid with trimethylene carbonate (P(L)LA-co-TMC) is used to fabricate a biomimetic electrospun scaffold and its potentialities for myocardial tissue engineering are investigated compared to poly(L)lactic acid (P(L)LA) electrospun scaffold.File in questo prodotto:
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