Medical devices and tissue engineered constructs may induce an inflammatory reaction - termed foreing body reaction (FBR) - after their in vivo implantation. Despite recent advances in material science and tissue engineering, current knowledge of the inflammatoory mechanism associated with FBR remains scanty. macrophage activation can be modulated by biomaterial topography according to the biological scale (micrometric and nanometric range). In this study we investigated the effect of fiber diamter and fiber alignement of electrospun Poly(L-lactic acid) (PLLA) scaffolds on macrophage RAW 264.7 activation and secretion of proinflammatory cytokines and chemokines at 24 and 7 days.
Effect of electrospun fiber diameter and alignment on macrophage activation and secretion of proinflammatory cytokines and chemokines
FOCARETE, MARIA LETIZIA;GUALANDI, CHIARA;
2011
Abstract
Medical devices and tissue engineered constructs may induce an inflammatory reaction - termed foreing body reaction (FBR) - after their in vivo implantation. Despite recent advances in material science and tissue engineering, current knowledge of the inflammatoory mechanism associated with FBR remains scanty. macrophage activation can be modulated by biomaterial topography according to the biological scale (micrometric and nanometric range). In this study we investigated the effect of fiber diamter and fiber alignement of electrospun Poly(L-lactic acid) (PLLA) scaffolds on macrophage RAW 264.7 activation and secretion of proinflammatory cytokines and chemokines at 24 and 7 days.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
