The basic approach to bone tissue engineering involves the development of highly porous biodegradable 3D-scaffolds, with interconnected pore network structure for cellular in-growth, revascularization, adequate nutrition and oxygen supply. Electrospinning is a simple and cost-effective technique that enables to fabricate scaffolds, both from synthetic and natural polymers, mimicking the three-dimensional nano-scaled features of ECM. Synthetic bioresorbable polymers provide structural functionalities to the scaffold. On the other hand, natural polymers display unique bioactive properties and excellent cellular affinity. In this work we developed new electrospun scaffolds made up of poly(L)lactic acid (PLLA) fibers and Type A gelatin fibers with the aim of combining the bioactivity of gelatin together with the structural stability of PLLA in a unique scaffold. Scaffolds were prepared by concomitantly electrospinning a PLLA solution and a gelatin solution and chemical-physical properties were evaluated and related to scaffold structure and composition.
M. Gioffrè, C. Gualandi, A. Fiorani, M.L. Focarete, S. Panzavolta, B. Bracci, et al. (2011). Electrospun gelatin-PLLA scaffolds. S.N. : s.n.
Electrospun gelatin-PLLA scaffolds
GUALANDI, CHIARA;FIORANI, ANDREA;FOCARETE, MARIA LETIZIA;PANZAVOLTA, SILVIA;BRACCI, BARBARA;BIGI, ADRIANA
2011
Abstract
The basic approach to bone tissue engineering involves the development of highly porous biodegradable 3D-scaffolds, with interconnected pore network structure for cellular in-growth, revascularization, adequate nutrition and oxygen supply. Electrospinning is a simple and cost-effective technique that enables to fabricate scaffolds, both from synthetic and natural polymers, mimicking the three-dimensional nano-scaled features of ECM. Synthetic bioresorbable polymers provide structural functionalities to the scaffold. On the other hand, natural polymers display unique bioactive properties and excellent cellular affinity. In this work we developed new electrospun scaffolds made up of poly(L)lactic acid (PLLA) fibers and Type A gelatin fibers with the aim of combining the bioactivity of gelatin together with the structural stability of PLLA in a unique scaffold. Scaffolds were prepared by concomitantly electrospinning a PLLA solution and a gelatin solution and chemical-physical properties were evaluated and related to scaffold structure and composition.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
