Abstract: The knowledge of the local atomic environment of copper in inorganic complexes containing scorpionate-based ligands is essential to study the relationship between cytotoxic activity and structure of the complexes. X-ray absorption spectroscopy (XAS) experiments at the XAFS 11.1 beamline allows to obtain the relevant structural information. The joint XAS and biological data evaluation can allow to design new ligands useful for the synthesis of novel copper derivatives to be further evaluated as alternative anticancer drugs.
Structural studies of copper complexes as potential bioinorganic target-specific drugs
GIORGETTI, MARCO;
2011
Abstract
Abstract: The knowledge of the local atomic environment of copper in inorganic complexes containing scorpionate-based ligands is essential to study the relationship between cytotoxic activity and structure of the complexes. X-ray absorption spectroscopy (XAS) experiments at the XAFS 11.1 beamline allows to obtain the relevant structural information. The joint XAS and biological data evaluation can allow to design new ligands useful for the synthesis of novel copper derivatives to be further evaluated as alternative anticancer drugs.File in questo prodotto:
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