The present invention relates to a portable device for the detection of analytes, in particular toxic substances, comprising at least a whole-cell biosensor with cells immobilized onto a transparent and inert matrix that allows the maintenance of cell vitality. The matrix comprises a mixture of collagen and/or its enzyme degradation derivatives, a proteoglycan and a mixture of vinyl polymer and an optionally modified polysiloxane, and an orthosilicate. The biosensor can be a genetically modified cell that expresses luciferase as reporter gene.
Michelini E, Roda A, Dolci L.S., Cevenini L., Mezzanotte L. (2010). PORTABLE DEVICE BASED ON IMMOBILIZED CELLS FOR THE DETECTION OF ANALYTES.
PORTABLE DEVICE BASED ON IMMOBILIZED CELLS FOR THE DETECTION OF ANALYTES
MICHELINI, ELISA;RODA, ALDO;DOLCI, LUISA STELLA;CEVENINI, LUCA;MEZZANOTTE, LAURA
2010
Abstract
The present invention relates to a portable device for the detection of analytes, in particular toxic substances, comprising at least a whole-cell biosensor with cells immobilized onto a transparent and inert matrix that allows the maintenance of cell vitality. The matrix comprises a mixture of collagen and/or its enzyme degradation derivatives, a proteoglycan and a mixture of vinyl polymer and an optionally modified polysiloxane, and an orthosilicate. The biosensor can be a genetically modified cell that expresses luciferase as reporter gene.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
