The fruits produced by plants of the Citrus genus and their hybrids, collectively known as agrumes, have been used as food since immemorial times. They contain many bioactive compounds that can have important effects on metabolism and health of human beings: for example, the exocarp of bitter orange and related species is used for hypocaloric diets since it is rich in adrenergic amines, which can have lipolytic and thermogenic effects. Other Citrus species contain coumarinic compounds, such as auraptene, that are prospective chemopreventive agents toward different kinds of cancer. Two methods have been developed for the analysis of bioactive compounds of Citrus fruits and derived dietary supplements. The first one is based on capillary electrophoresis (CZE) and is suitable for the determination of three adrenergic amines (synephrine, octopamine and tyramine), as well as ephedrine, which is currently forbidden in supplements. The second method is based on HPLC-F and is suitable for the quantitative analysis of auraptene and umbelliferone in Citrus fruits and related products. Both methods have been validated according to international guidelines.
R. Mandrioli, L. Mercolini, E. Morganti, A. Ferranti, S. Benazzi, F. Poli, et al. (2011). Nutraceutical Citrus fruits: activity on metabolism and chemoprevention. BOLOGNA : Alma Mater Studiorum - Università di Bologna.
Nutraceutical Citrus fruits: activity on metabolism and chemoprevention
MANDRIOLI, ROBERTO;MERCOLINI, LAURA;MORGANTI, EMANUELE;FERRANTI, ANNA;POLI, FERRUCCIO;RAGGI, MARIA AUGUSTA
2011
Abstract
The fruits produced by plants of the Citrus genus and their hybrids, collectively known as agrumes, have been used as food since immemorial times. They contain many bioactive compounds that can have important effects on metabolism and health of human beings: for example, the exocarp of bitter orange and related species is used for hypocaloric diets since it is rich in adrenergic amines, which can have lipolytic and thermogenic effects. Other Citrus species contain coumarinic compounds, such as auraptene, that are prospective chemopreventive agents toward different kinds of cancer. Two methods have been developed for the analysis of bioactive compounds of Citrus fruits and derived dietary supplements. The first one is based on capillary electrophoresis (CZE) and is suitable for the determination of three adrenergic amines (synephrine, octopamine and tyramine), as well as ephedrine, which is currently forbidden in supplements. The second method is based on HPLC-F and is suitable for the quantitative analysis of auraptene and umbelliferone in Citrus fruits and related products. Both methods have been validated according to international guidelines.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
