The global opioid landscape has undergone a profound transformation in recent years, marked by the emergence and rapid proliferation of potent synthetic ana- logues that have reshaped both drug markets and public health priorities. Initially dominated by the spread of fentanyl and its analogues, the opioid crisis has progres- sively evolved towards the diffusion of novel chemical classes such as benzimid- azole opioids (nitazenes), U-series compounds and other structurally unrelated synthetic opioids, collectively known as “new synthetic opioids” (NSOs).
Protti, M., Mandrioli, R., Mercolini, L. (2026). Chapter 15. Difficulty in Detecting Opioid-Like Designer Drugs. Cham : Springer Nature Switzerland [10.1007/978-3-032-15015-8_15].
Chapter 15. Difficulty in Detecting Opioid-Like Designer Drugs
Protti, MichelePrimo
Membro del Collaboration Group
;Mandrioli, RobertoSecondo
Membro del Collaboration Group
;Mercolini, Laura
Ultimo
2026
Abstract
The global opioid landscape has undergone a profound transformation in recent years, marked by the emergence and rapid proliferation of potent synthetic ana- logues that have reshaped both drug markets and public health priorities. Initially dominated by the spread of fentanyl and its analogues, the opioid crisis has progres- sively evolved towards the diffusion of novel chemical classes such as benzimid- azole opioids (nitazenes), U-series compounds and other structurally unrelated synthetic opioids, collectively known as “new synthetic opioids” (NSOs).I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.



