The association of unhealthy lifestyles (high calorie intake, low physical activity) with insulin resistance and the presence of liver fat (NAFLD) is well established. Reduced calorie intake and physical exercise exert a synergistic effect on insulin sensitivity and favor the removal of triglycerides and free fatty acids from the hepatocytes. The adherence to lifestyle changes and the maintenance of long-term weight loss can only be achieved by a behavioral approach. Very few studies have so far tested the effectiveness of lifestyle approach in the prevention of fatty liver progression to advanced fibrosis and cirrhosis, assessed by liver histology. Due to time constraints in busy liver units, hepatologists might limit their activity to engaging patients and refer them to teams operating in the area of diabetes and obesity, including dietitians, psychologists, and exercise experts. Prevention programs should address the problem of nonalcoholic fatty liver in childhood.
G. Marchesini Reggiani, C. Nuccitelli, E. Centis, S. Di Domizio, A. Suppini, R. Marzocchi, et al. (2011). Behavioral aspects of nonalcoholic fatty liver disease: diet, causes, and treatment. NEW YORK/HEIDELBERG : Springer [10.1007/978-0-387-92271-3_119].
Behavioral aspects of nonalcoholic fatty liver disease: diet, causes, and treatment
MARCHESINI REGGIANI, GIULIO;CENTIS, ELENA;DI DOMIZIO, SILVIA;SUPPINI, ALESSANDRO;MARZOCCHI, REBECCA;
2011
Abstract
The association of unhealthy lifestyles (high calorie intake, low physical activity) with insulin resistance and the presence of liver fat (NAFLD) is well established. Reduced calorie intake and physical exercise exert a synergistic effect on insulin sensitivity and favor the removal of triglycerides and free fatty acids from the hepatocytes. The adherence to lifestyle changes and the maintenance of long-term weight loss can only be achieved by a behavioral approach. Very few studies have so far tested the effectiveness of lifestyle approach in the prevention of fatty liver progression to advanced fibrosis and cirrhosis, assessed by liver histology. Due to time constraints in busy liver units, hepatologists might limit their activity to engaging patients and refer them to teams operating in the area of diabetes and obesity, including dietitians, psychologists, and exercise experts. Prevention programs should address the problem of nonalcoholic fatty liver in childhood.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
