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EnglishObjectives: A light-curing resin-modified calcium-silicate cement was designed to obtain a bioactive calciumreleasing remineralizing material (Ic-MTA) for rehabilitation of deciduous teeth and remineralization of dentine lesions. Materials and methods: Ic-MTA was prepared by mixing a tailored calcium-silicate bioactive filler with an anphiphilic HEMA/TEGDMA-based resin. Calcium release and alkalinizing activity (i.e. pH of soaking water) of the cement were tested. The dentine remineralization capability and the bioactivity (i.e. apatite-forming ability) were investigated by ATR-FTIR and ESEM/EDX analyses after immersion in DPBS at 37 ◦C for 7 days. Dentine disks 0.8±0.2mm thick were obtained from coronal side of healthy third molars and demineralized in 15mL of sterile 17% EDTA for 2h. EDX element distribution maps confirmed the complete absence of apatite on dentine disks from the surface to a 10 microns depth. Results: The experimental material releases calcium (200ppm at 3 h), increases the environmental pH to 10–11 and showed marked bioactivity. After 7 days a thick layer of carbonated apatite (Ap) was noticed on dentine surface. Apatite precipitates obturated the dentinal tubules. Conclusions: Calcium-silicate materials are bioactive. Silanol groups from the mineral particles induce heterogeneous nucleation of apatite by sorption of calcium and phosphate ions. The improved bioactivity of Ic-MTA is related to the oxygen-containing groups from HEMA/TEGDMA, which provide additional apatite nucleating sites through the formation of calcium chelates. An improved biomimetic remineralization of dentine and a faster bioactive behaviour was proved by the novel light-curing calcium-silicate material. The coupling of a hydraulic calcium-silicate powder with a HEMA-TEGDMA hydrophilic resin creates conditions (enhanced calcium release and functional groups able to chelate Ca ions, with a consequent rapid apatite deposition) promising for the remineralization and regeneration of mineral hard tissues.
| Titolo: | Biomimetic dentine remineralization by a novel bioactive light-curing calcium-silicate composite | |
| Autore/i: | GANDOLFI, MARIA GIOVANNA; SIBONI, FRANCESCO; TADDEI, PAOLA; MODENA, ENRICO; PRATI, CARLO | |
| Autore/i Unibo: | ||
| Anno: | 2010 | |
| Rivista: | ||
| Pagina iniziale: | e71 | |
| Pagina finale: | e72 | |
| Abstract: | Objectives: A light-curing resin-modified calcium-silicate cement was designed to obtain a bioactive calciumreleasing remineralizing material (Ic-MTA) for rehabilitation of deciduous teeth and remineralization of dentine lesions. Materials and methods: Ic-MTA was prepared by mixing a tailored calcium-silicate bioactive filler with an anphiphilic HEMA/TEGDMA-based resin. Calcium release and alkalinizing activity (i.e. pH of soaking water) of the cement were tested. The dentine remineralization capability and the bioactivity (i.e. apatite-forming ability) were investigated by ATR-FTIR and ESEM/EDX analyses after immersion in DPBS at 37 ◦C for 7 days. Dentine disks 0.8±0.2mm thick were obtained from coronal side of healthy third molars and demineralized in 15mL of sterile 17% EDTA for 2h. EDX element distribution maps confirmed the complete absence of apatite on dentine disks from the surface to a 10 microns depth. Results: The experimental material releases calcium (200ppm at 3 h), increases the environmental pH to 10–11 and showed marked bioactivity. After 7 days a thick layer of carbonated apatite (Ap) was noticed on dentine surface. Apatite precipitates obturated the dentinal tubules. Conclusions: Calcium-silicate materials are bioactive. Silanol groups from the mineral particles induce heterogeneous nucleation of apatite by sorption of calcium and phosphate ions. The improved bioactivity of Ic-MTA is related to the oxygen-containing groups from HEMA/TEGDMA, which provide additional apatite nucleating sites through the formation of calcium chelates. An improved biomimetic remineralization of dentine and a faster bioactive behaviour was proved by the novel light-curing calcium-silicate material. The coupling of a hydraulic calcium-silicate powder with a HEMA-TEGDMA hydrophilic resin creates conditions (enhanced calcium release and functional groups able to chelate Ca ions, with a consequent rapid apatite deposition) promising for the remineralization and regeneration of mineral hard tissues. | |
| Data prodotto definitivo in UGOV: | 28-feb-2011 | |
| Appare nelle tipologie: | 4.02 Riassunto (Abstract) |
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