MANERBA, MARCELLA
MANERBA, MARCELLA
DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE (attivo dal 28/10/2011 al 31/12/2022)
Assegnisti
The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination
2022 Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Poppi, Laura; Gennari, Arianna; Rinaldi, Francesco; Armirotti, Andrea; Farabegoli, Fulvia; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Girotto, Stefania; Tirelli, Nicola; Cavalli, Andrea
Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment
2021 Balboni, A.; Govoni, M.; Rossi, V.; Roberti, M.; Cavalli, A.; Di Stefano, G.; Manerba, M.
Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin
2021 Govoni M.; Rossi V.; Di Stefano G.; Manerba M.
RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer
2021 Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Gennari, Arianna; Rinaldi, Francesco; Armirotti, Andrea; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Tirelli, Nicola; Girotto, Stefania; Cavalli, Andrea
Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib
2020 Bagnolini G.; Milano D.; Manerba M.; Schipani F.; Ortega J.A.; Gioia D.; Falchi F.; Balboni A.; Farabegoli F.; De Franco F.; Robertson J.; Pellicciari R.; Pallavicini I.; Peri S.; Minucci S.; Girotto S.; Di Stefano G.; Roberti M.; Cavalli A.
Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir
2019 Manerba, Marcella; Govoni, Marzia; Manet, Ilse; Leale, Antoniofrancesco; Comparone, Antonietta; Di Stefano, Giuseppina
Rad51/Brca2 Disruptors Inhibit Homologous Recombination and Synergize with Olaparib in Pancreatic Cancer Cells
2019 Marinella Roberti, Fabrizio Schipani, Greta Bagnolini, Domenico Milano, Elisa Giacomini, Federico Falchi, Andrea Balboni, Marcella Manerba, Fulvia Farabegoli, Francesca De Franco, Janet Robertson, Saverio Minucci, Isabella Pallavicini, Giuseppina Di Stefano, Stefania Girotto, Roberto Pellicciari, and Andrea Cavalli
The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells
2018 Manerba M, Di Ianni L, Govoni M, Comparone A, Di Stefano G.
Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells
2017 Manerba, Marcella; Di Ianni, Lorenza; Govoni, Marzia; Roberti, Marinella; Recanatini, Maurizio; Di Stefano, Giuseppina
LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells
2017 Manerba, Marcella; Di Ianni, Lorenza; Govoni, Marzia; Roberti, Marinella; Recanatini, Maurizio; Di Stefano, Giuseppina
Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors
2017 Falchi, Federico; Giacomini, Elisa; Masini, Tiziana; Boutard, Nicolas; Di Ianni, Lorenza; Manerba, Marcella; Farabegoli, Fulvia; Rossini, Lara; Robertson, Janet; Minucci, Saverio; Pallavicini, Isabella; Di Stefano, Giuseppina; Roberti, Marinella; Pellicciari, Roberto; Cavalli, Andrea
Lactate dehydrogenase inhibition: Exploring possible applications beyond cancer treatment
2016 Di Stefano, Giuseppina; Manerba, Marcella; Di Ianni, Lorenza; Fiume, Luigi
Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A
2016 Rupiani, Sebastiano; Guidotti, Laura; Manerba, Marcella; DI IANNI, Lorenza; Giacomini, Elisa; Falchi, Federico; DI STEFANO, Giuseppina; Roberti, Marinella; Recanatini, Maurizio
Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors
2015 Sebastiano Rupiani; Rosa Buonfiglio; Marcella Manerba; Lorenza Di Ianni; Marina Vettraino; Elisa Giacomini; Matteo Masetti; Federico Falchi; Giuseppina Di Stefano; Marinella Roberti; Maurizio Recanatini
Lactate dehydrogenase inhibitors sensitize lymphoma cells to cisplatin without enhancing the drug effects on immortalized normal lymphocytes.
2015 M. Manerba; L. Di Ianni; L. Fiume; M. Roberti; M. Recanatini; G. Di Stefano
Albumin-drug conjugates in the treatment of hepatic disorders.
2014 Fiume L;Manerba M;Di Stefano G
Inhibition of lactate dehydrogenase activity as an approach to cancer therapy
2014 Luigi FIUME; Marcella MANERBA; Marina VETTRAINO; Giuseppina DI STEFANO
Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulationin Burkitt lymphoma cells via NAD/NADH-dependent inhibition of sirtuin-1
2013 Vettraino M; Manerba M; Govoni M; Di Stefano G.
NAD metabolism and functions: a common therapeutic target for neoplastic, metabolic and neurodegenerative diseases
2013 Di Stefano G; Manerba M; Vettraino M
Galloflavin (CAS 568-80-9), a novel inhibitor of lactate dehydrogenase.
2012 Manerba M.; Vettraino M.; Fiume L.; Di Stefano G.; Sartini A.; Giacomini E.; Buonfiglio R.; Roberti M.; Recanatini M.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| The Mechanistic Understanding of RAD51 Defibrillation: A Critical Step in BRCA2-Mediated DNA Repair by Homologous Recombination | Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Poppi, Laura; Gennari, Arianna; Rinaldi,... Francesco; Armirotti, Andrea; Farabegoli, Fulvia; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Girotto, Stefania; Tirelli, Nicola; Cavalli, Andrea | 2022-01-01 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - | 1.01 Articolo in rivista | ijms-23-08338-v3 (1).pdf |
| Lactate dehydrogenase inhibition affects homologous recombination repair independently of cell metabolic asset; implications for anticancer treatment | Balboni, A.; Govoni, M.; Rossi, V.; Roberti, M.; Cavalli, A.; Di Stefano, G.; Manerba, M. | 2021-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | - | 1.01 Articolo in rivista | Revised Text BBA 2020.pdf |
| Lactate Upregulates the Expression of DNA Repair Genes, Causing Intrinsic Resistance of Cancer Cells to Cisplatin | Govoni M.; Rossi V.; Di Stefano G.; Manerba M. | 2021-01-01 | PATHOLOGY ONCOLOGY RESEARCH | - | 1.01 Articolo in rivista | POR journal 2021.pdf |
| RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer | Schipani, Fabrizio; Manerba, Marcella; Marotta, Roberto; Gennari, Arianna; Rinaldi, Francesco; Ar...mirotti, Andrea; Roberti, Marinella; Di Stefano, Giuseppina; Rocchia, Walter; Tirelli, Nicola; Girotto, Stefania; Cavalli, Andrea | 2021-01-01 | bioRxiv | - | 1.01 Articolo in rivista | - |
| Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib | Bagnolini G.; Milano D.; Manerba M.; Schipani F.; Ortega J.A.; Gioia D.; Falchi F.; Balboni A.; F...arabegoli F.; De Franco F.; Robertson J.; Pellicciari R.; Pallavicini I.; Peri S.; Minucci S.; Girotto S.; Di Stefano G.; Roberti M.; Cavalli A. | 2020-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | ASAP_acs.jmedchem.9b01526.pdf |
| Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir | Manerba, Marcella; Govoni, Marzia; Manet, Ilse; Leale, Antoniofrancesco; Comparone, Antonietta; D...i Stefano, Giuseppina | 2019-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | - | 1.01 Articolo in rivista | - |
| Rad51/Brca2 Disruptors Inhibit Homologous Recombination and Synergize with Olaparib in Pancreatic Cancer Cells | Marinella Roberti, Fabrizio Schipani, Greta Bagnolini, Domenico Milano, Elisa Giacomini, Federico... Falchi, Andrea Balboni, Marcella Manerba, Fulvia Farabegoli, Francesca De Franco, Janet Robertson, Saverio Minucci, Isabella Pallavicini, Giuseppina Di Stefano, Stefania Girotto, Roberto Pellicciari, and Andrea Cavalli | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells | Manerba M, Di Ianni L, Govoni M, Comparone A, Di Stefano G. | 2018-01-01 | PLOS ONE | - | 1.01 Articolo in rivista | PONE 2018.pdf |
| Lactate dehydrogenase inhibitors can reverse inflammation induced changes in colon cancer cells | Manerba, Marcella; Di Ianni, Lorenza; Govoni, Marzia; Roberti, Marinella; Recanatini, Maurizio; D...i Stefano, Giuseppina | 2017-01-01 | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | - | 1.01 Articolo in rivista | manerba_2107.pdf |
| LDH inhibition impacts on heat shock response and induces senescence of hepatocellular carcinoma cells | Manerba, Marcella; Di Ianni, Lorenza; Govoni, Marzia; Roberti, Marinella; Recanatini, Maurizio; D...i Stefano, Giuseppina | 2017-01-01 | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | - | 1.01 Articolo in rivista | Bozza finale_PHASCI_4029_final.pdf |
| Synthetic Lethality Triggered by Combining Olaparib with BRCA2-Rad51 Disruptors | Falchi, Federico; Giacomini, Elisa; Masini, Tiziana; Boutard, Nicolas; Di Ianni, Lorenza; Manerba..., Marcella; Farabegoli, Fulvia; Rossini, Lara; Robertson, Janet; Minucci, Saverio; Pallavicini, Isabella; Di Stefano, Giuseppina; Roberti, Marinella; Pellicciari, Roberto; Cavalli, Andrea | 2017-01-01 | ACS CHEMICAL BIOLOGY | - | 1.01 Articolo in rivista | - |
| Lactate dehydrogenase inhibition: Exploring possible applications beyond cancer treatment | Di Stefano, Giuseppina; Manerba, Marcella; Di Ianni, Lorenza; Fiume, Luigi | 2016-01-01 | FUTURE MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Synthesis of natural urolithin M6, a galloflavin mimetic, as a potential inhibitor of lactate dehydrogenase A | Rupiani, Sebastiano; Guidotti, Laura; Manerba, Marcella; DI IANNI, Lorenza; Giacomini, Elisa; Fal...chi, Federico; DI STEFANO, Giuseppina; Roberti, Marinella; Recanatini, Maurizio | 2016-01-01 | ORGANIC & BIOMOLECULAR CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Identification of N-acylhydrazone derivatives as novel lactate dehydrogenase A inhibitors | Sebastiano Rupiani; Rosa Buonfiglio; Marcella Manerba; Lorenza Di Ianni; Marina Vettraino; Elisa ...Giacomini; Matteo Masetti; Federico Falchi; Giuseppina Di Stefano; Marinella Roberti; Maurizio Recanatini | 2015-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Lactate dehydrogenase inhibitors sensitize lymphoma cells to cisplatin without enhancing the drug effects on immortalized normal lymphocytes. | M. Manerba; L. Di Ianni; L. Fiume; M. Roberti; M. Recanatini; G. Di Stefano | 2015-01-01 | EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES | - | 1.01 Articolo in rivista | REVISED TEXT-1.pdf |
| Albumin-drug conjugates in the treatment of hepatic disorders. | Fiume L;Manerba M;Di Stefano G | 2014-01-01 | EXPERT OPINION ON DRUG DELIVERY | - | 1.01 Articolo in rivista | - |
| Inhibition of lactate dehydrogenase activity as an approach to cancer therapy | Luigi FIUME; Marcella MANERBA; Marina VETTRAINO; Giuseppina DI STEFANO | 2014-01-01 | FUTURE MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulationin Burkitt lymphoma cells via NAD/NADH-dependent inhibition of sirtuin-1 | Vettraino M; Manerba M; Govoni M; Di Stefano G. | 2013-01-01 | ANTI-CANCER DRUGS | - | 1.01 Articolo in rivista | - |
| NAD metabolism and functions: a common therapeutic target for neoplastic, metabolic and neurodegenerative diseases | Di Stefano G; Manerba M; Vettraino M | 2013-01-01 | CURRENT TOPICS IN MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Galloflavin (CAS 568-80-9), a novel inhibitor of lactate dehydrogenase. | Manerba M.; Vettraino M.; Fiume L.; Di Stefano G.; Sartini A.; Giacomini E.; Buonfiglio R.; Rober...ti M.; Recanatini M. | 2012-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | - |