The unprecedented cyclotetrapeptide 2, c[D-Asp-1-amide-betaAla-D-Trp-Phe], shows a nanomolar MOR affinity, albeit deprived of any ionic interaction. 2 Shows a clear D-Trpi+1-Phei+2 beta-turn in solution as well in the receptor-bound state. This compound may represent the lead for novel, atypical liphophilic opioid ligands.
DETERMINATION OF THE BIOLOGICALLY ACTIVE STRUCTURE OF THE ATYPICAL MOR-LIGAND c[D-Asp-1-amide-beta-Ala-D-Trp-Phe] AND ANALOGUES BY NMR AND MOLECULAR DOCKING
GENTILUCCI, LUCA;TOLOMELLI, ALESSANDRA;SPAMPINATO, SANTI MARIO;BEDINI, ANDREA;DE MARCO, ROSSELLA;
2010
Abstract
The unprecedented cyclotetrapeptide 2, c[D-Asp-1-amide-betaAla-D-Trp-Phe], shows a nanomolar MOR affinity, albeit deprived of any ionic interaction. 2 Shows a clear D-Trpi+1-Phei+2 beta-turn in solution as well in the receptor-bound state. This compound may represent the lead for novel, atypical liphophilic opioid ligands.File in questo prodotto:
Eventuali allegati, non sono esposti
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.