The oral cavity, as the first part of the digestive system, is a reservoir of pathogens for focal infections and the site of origin for dissemination of microbial cells and products. Theoretically, the mechanisms by which oral bacteria may cause non oral diseases in other sites of the GIT are: by translocation of bacteria and their virulence factors, such as toxins, and by immunological imbalance for specific antibodies cross reaction [1]. In fact, oral pathogens, during bacteraemia, can spread their toxins through the bloodstream or through the neighbouring GI sites. Moreover, recent studies have focused on the link between the composition of oral and intestinal microbiota in IBD (Irritable Bowel Disease) patients, and have speculated about a relationship between oral and intestinal diseases. Therefore, to control the colonisation of pathogenic bacteria in the mouth is the first step to limit the dissemination of virulence factors through the GIT.
DECREASE IN TOXINS EXPRESSION OF AN ORAL PATHOGEN BY PROBIOTICS / Nissen L.; Sgorbati B.; Belibasakis G.. - In: GUT. - ISSN 0017-5749. - STAMPA. - 59 (Suppl III):(2010), pp. P1286-P1286. (Intervento presentato al convegno 18th UEGW Barcellona tenutosi a Barcellona nel 23-27 October 2010).
DECREASE IN TOXINS EXPRESSION OF AN ORAL PATHOGEN BY PROBIOTICS
NISSEN, LORENZO;SGORBATI, BARBARA;
2010
Abstract
The oral cavity, as the first part of the digestive system, is a reservoir of pathogens for focal infections and the site of origin for dissemination of microbial cells and products. Theoretically, the mechanisms by which oral bacteria may cause non oral diseases in other sites of the GIT are: by translocation of bacteria and their virulence factors, such as toxins, and by immunological imbalance for specific antibodies cross reaction [1]. In fact, oral pathogens, during bacteraemia, can spread their toxins through the bloodstream or through the neighbouring GI sites. Moreover, recent studies have focused on the link between the composition of oral and intestinal microbiota in IBD (Irritable Bowel Disease) patients, and have speculated about a relationship between oral and intestinal diseases. Therefore, to control the colonisation of pathogenic bacteria in the mouth is the first step to limit the dissemination of virulence factors through the GIT.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
