High-throughput ion channel screening for drug discovery is the gold standard for investigating the function of chan- nel proteins and it is at the base of the recent shift of resources in the pharmaceutical industry towards addressing drug safety issues earlier in the discovery process. This paper presents a versatile, low-cost and disposable microfluidic device realized using a micromilling process fa- brication of polyoxymethilene homopolymer (DelrinTM) substrates. The devices are suitable to host lipid bilayer mem- brane arrays for ion channel recording activities using a fully automated approach and are embedded in a parallel readout hybrid electronic system.
A Disposable Microfluidic Array Platform for Automatic Ion Channel Recording / M. Rossi; F. Thei; H. Morgan; M. Tartagni. - STAMPA. - (2010), pp. 1913-1915. (Intervento presentato al convegno Micro-TAS 2010 tenutosi a Groningen (NL) nel 3 - 7 October 2010).
A Disposable Microfluidic Array Platform for Automatic Ion Channel Recording
ROSSI, MICHELE;THEI, FEDERICO;TARTAGNI, MARCO
2010
Abstract
High-throughput ion channel screening for drug discovery is the gold standard for investigating the function of chan- nel proteins and it is at the base of the recent shift of resources in the pharmaceutical industry towards addressing drug safety issues earlier in the discovery process. This paper presents a versatile, low-cost and disposable microfluidic device realized using a micromilling process fa- brication of polyoxymethilene homopolymer (DelrinTM) substrates. The devices are suitable to host lipid bilayer mem- brane arrays for ion channel recording activities using a fully automated approach and are embedded in a parallel readout hybrid electronic system.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
