We developed a new comprehensive cardiopulmonary model that takes into account the mutual interactions between the cardiovascular and the respiratory systems along with their short-term regulatory mechanisms. The model includes the heart, systemic and pulmonary circulations, lung mechanics, gas exchange and transport equations, and cardio-ventilatory control. Results show good agreement with published patient data in case of normoxic and hyperoxic hypercapnia simulations. In particular, simulations predict a moderate increase in mean systemic arterial pressure and heart rate, with almost no change in cardiac output, paralleled by a relevant increase in minute ventilation, tidal volume and respiratory rate. The model can represent a valid tool for clinical practice and medical research, providing an alternative way to experience-based clinical decisions.
A comprehensive cardiopulmonary simulation model for the analysis of hypercapnic respiratory failure / N. W. Chbat; M. Giannessi; A. Albanese; M. Ursino. - ELETTRONICO. - (2009), pp. 5474-5477. (Intervento presentato al convegno 31th Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2007 (EMBC 2009) tenutosi a Minneapolis (USA) nel September, 2-6, 2009) [10.1109/IEMBS.2009.5334567].
A comprehensive cardiopulmonary simulation model for the analysis of hypercapnic respiratory failure
GIANNESSI, MASSIMO;URSINO, MAURO
2009
Abstract
We developed a new comprehensive cardiopulmonary model that takes into account the mutual interactions between the cardiovascular and the respiratory systems along with their short-term regulatory mechanisms. The model includes the heart, systemic and pulmonary circulations, lung mechanics, gas exchange and transport equations, and cardio-ventilatory control. Results show good agreement with published patient data in case of normoxic and hyperoxic hypercapnia simulations. In particular, simulations predict a moderate increase in mean systemic arterial pressure and heart rate, with almost no change in cardiac output, paralleled by a relevant increase in minute ventilation, tidal volume and respiratory rate. The model can represent a valid tool for clinical practice and medical research, providing an alternative way to experience-based clinical decisions.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
