Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.
COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial / Agrati C.; Di Cosimo S.; Fenoglio D.; Apolone G.; Ciceri F.; Ciliberto G.; Baldanti F.; Costantini M.; Giannarelli D.; Ippolito G.; Locatelli F.; Mantovani A.; Morrone A.; Tagliavini F.; Uccelli A.; Zinzani P.L.; Silvestris N.; Rescigno M.. - In: FRONTIERS IN IMMUNOLOGY. - ISSN 1664-3224. - ELETTRONICO. - 12:(2021), pp. 704110-704110. [10.3389/fimmu.2021.704110]
COVID-19 Vaccination in Fragile Patients: Current Evidence and an Harmonized Transdisease Trial
Zinzani P. L.;
2021
Abstract
Patients diagnosed with malignancy, neurological and immunological disorders, i.e., fragile patients, have been excluded from COVID-19 vaccine trials. However, this population may present immune response abnormalities, and relative reduced vaccine responsiveness. Here we review the limited current evidence on the immune responses to vaccination of patients with different underlying diseases. To address open questions we present the VAX4FRAIL study aimed at assessing immune responses to vaccination in a large transdisease cohort of patients with cancer, neurological and rheumatological diseases.| File | Dimensione | Formato | |
|---|---|---|---|
|
fimmu-12-704110.pdf
accesso aperto
Tipo:
Versione (PDF) editoriale
Licenza:
Licenza per Accesso Aperto. Creative Commons Attribuzione (CCBY)
Dimensione
812.23 kB
Formato
Adobe PDF
|
812.23 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
