Heavy alcohol consumption is associated with increased overall mortality, cancer, liver, and cardiovascular diseases; but low doses of alcohol (up to one drink per day) are not associated with the risk of any cancer site with the exception of breast cancer and possibly of oral and pharyngeal cancers. Moreover, recent evidence indicates that moderate alcohol and specifically wine intake provides cardioprotection and neuroprotection and may increase longevity. Various experimental data hypothesize a potential cancer chemopreventive role of some grape extracts, and complete sequencing of the grapevine genome has revealed genes responsible for the synthesis of health-promoting compounds (resveratrol and other polyphenols), thus advocating the development of future potential nutraceutical strategies. This focuses on the pros and cons of moderate alcohol and wine consumption and opens a debate on this topic. European Journal of Cancer Prevention 21:103-108 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. RI gerbi, vincenzo/G-4457-2012
Alcohol and wine in relation to cancer and other diseases / Giacosa A; Adam-Blondon AF; Baer-Sinnott S; Barale R; Bavaresco L; Di Gaspero G; Dugo L; Ellison RC; Gerbi V; Gifford D; Janssens J; La Vecchia C; Negri E; Pezzotti M; Santi L; Santi L; Rondanelli M. - In: EUROPEAN JOURNAL OF CANCER PREVENTION. - ISSN 0959-8278. - 21:1(2012), pp. 103-108. [10.1097/CEJ.0b013e32834761d3]
Alcohol and wine in relation to cancer and other diseases
Negri E;
2012
Abstract
Heavy alcohol consumption is associated with increased overall mortality, cancer, liver, and cardiovascular diseases; but low doses of alcohol (up to one drink per day) are not associated with the risk of any cancer site with the exception of breast cancer and possibly of oral and pharyngeal cancers. Moreover, recent evidence indicates that moderate alcohol and specifically wine intake provides cardioprotection and neuroprotection and may increase longevity. Various experimental data hypothesize a potential cancer chemopreventive role of some grape extracts, and complete sequencing of the grapevine genome has revealed genes responsible for the synthesis of health-promoting compounds (resveratrol and other polyphenols), thus advocating the development of future potential nutraceutical strategies. This focuses on the pros and cons of moderate alcohol and wine consumption and opens a debate on this topic. European Journal of Cancer Prevention 21:103-108 (C) 2011 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. RI gerbi, vincenzo/G-4457-2012I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
