The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetics 1-8 are essentially determined by the predisposition of the diamine to stabilize -turns. The peptide mimetics can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as alfavbeta3-integrin receptor antagonists
Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic beta-Turn Templates and Validation as 3D Scaffolds / L. Gentilucci; G. Cardillo; A. Tolomelli; R. De Marco; A. Garelli; S. Spampinato; A. Spartà; E. Juaristi. - In: CHEMMEDCHEM. - ISSN 1860-7179. - STAMPA. - 4:(2009), pp. 517-523. [10.1002/cmdc.200800407]
Synthesis and Conformational Analysis of Cyclotetrapeptide Mimetic beta-Turn Templates and Validation as 3D Scaffolds
GENTILUCCI, LUCA;CARDILLO, GIULIANA;TOLOMELLI, ALESSANDRA;DE MARCO, ROSSELLA;GARELLI, ANDREA;SPAMPINATO, SANTI MARIO;
2009
Abstract
The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetics 1-8 are essentially determined by the predisposition of the diamine to stabilize -turns. The peptide mimetics can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as alfavbeta3-integrin receptor antagonistsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
