Background: Orthotopic heart transplantation (OHT) remains the gold standard for the treatment of end-stage heart failure. The number of patients who have had at least one prior sternotomy while awaiting transplantation has increased over the years reaching 50% in the last ISHLT registry report. We analysed our institutional transplant activity focusing on prior-sternotomy setting to identify the real burden of this preoperative variable and its potential consequences. Methods: Between 2000 and 2020, a total of 512 consecutive adult patients underwent OHT. We divided them into two groups according to the previous sternotomy variable: a prior sternotomy group (PS-group, n = 131, 25.6%) and a heart transplant as first sternotomy group (FS-group, n = 381, 74.4%). After propensity score matching, a total of 106 matched-pairs were identified for the final analysis. Results: The overall 30-day mortality was similar in the two groups (7.5% vs. 5.7%, p =.58). The prior sternotomy was not an independent risk factor for 90-day mortality (odds ratio: 0.89, p =.81). In the matched sample, prior cardiac surgery was not predictive for any major postoperative complication: primary graft failure, AKI, bleeding, acute respiratory insufficiency, need for extra-corporeal life support (p >.05). The log-rank test revealed no significant difference between the two groups in the unmatched and matched pools (p =.93 and 0.69 respectively. At univariable analysis prior sternotomy was not associated with an increased risk of posttransplant mortality (hazard ratio: 0.87, p =.599). Conclusions: Despite it increases surgical complexity, the reoperation alone does not represent a proper risk factor and among different co-variates that may affect post-OHT outcomes.

Impact of prior sternotomy on survival and allograft function after heart transplantation: A single center matched analysis

Mariani C.;Loforte A.;Gliozzi G.;Cavalli G. G.;Botta L.;Martin Suarez S.;Potena L.;Pacini D.
2022

Abstract

Background: Orthotopic heart transplantation (OHT) remains the gold standard for the treatment of end-stage heart failure. The number of patients who have had at least one prior sternotomy while awaiting transplantation has increased over the years reaching 50% in the last ISHLT registry report. We analysed our institutional transplant activity focusing on prior-sternotomy setting to identify the real burden of this preoperative variable and its potential consequences. Methods: Between 2000 and 2020, a total of 512 consecutive adult patients underwent OHT. We divided them into two groups according to the previous sternotomy variable: a prior sternotomy group (PS-group, n = 131, 25.6%) and a heart transplant as first sternotomy group (FS-group, n = 381, 74.4%). After propensity score matching, a total of 106 matched-pairs were identified for the final analysis. Results: The overall 30-day mortality was similar in the two groups (7.5% vs. 5.7%, p =.58). The prior sternotomy was not an independent risk factor for 90-day mortality (odds ratio: 0.89, p =.81). In the matched sample, prior cardiac surgery was not predictive for any major postoperative complication: primary graft failure, AKI, bleeding, acute respiratory insufficiency, need for extra-corporeal life support (p >.05). The log-rank test revealed no significant difference between the two groups in the unmatched and matched pools (p =.93 and 0.69 respectively. At univariable analysis prior sternotomy was not associated with an increased risk of posttransplant mortality (hazard ratio: 0.87, p =.599). Conclusions: Despite it increases surgical complexity, the reoperation alone does not represent a proper risk factor and among different co-variates that may affect post-OHT outcomes.
Mariani C.; Loforte A.; Gliozzi G.; Cavalli G.G.; Botta L.; Martin Suarez S.; Potena L.; Pacini D.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/860239
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