Objective: Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity. Methods: Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (n = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume. Results: We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes. Conclusions: Larger sample sizes are required to detect moderate effects.
Genome-wide association study of suicidal behaviour severity in mood disorders / Zai C.C.; Fabbri C.; Hosang G.M.; Zhang R.S.; Koyama E.; de Luca V.; Tiwari A.K.; King N.; Strauss J.; Jones I.; Jones L.; Breen G.; Farmer A.E.; McGuffin P.; Vincent J.B.; Kennedy J.L.; Lewis C.M.. - In: THE WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY. - ISSN 1562-2975. - STAMPA. - 22:9(2021), pp. 722-731. [10.1080/15622975.2021.1907711]
Genome-wide association study of suicidal behaviour severity in mood disorders
Fabbri C.;
2021
Abstract
Objective: Suicide is a major public health problem and it has a prominent genetic component. We performed a genome-wide association study (GWAS) of suicidal behaviour severity. Methods: Suicide behaviour severity was assessed within the Schedules for Clinical Assessment in Neuropsychiatry in our mood disorder sample (n = 3506) for the GWAS. We also performed polygenic risk score analyses to explore genetic sharing between suicidal behaviour severity and a number of phenotypes, including bipolar disorder, major depressive disorder, alcoholism, post-traumatic stress disorder, impulsivity, insomnia, educational attainment, loneliness, maltreatment, and amygdala volume. Results: We did not detect genome-wide significant findings at the single-marker or gene level. We report a number of suggestive single-marker and gene-based findings. Our polygenic risk score analyses did not yield significant findings with these phenotypes. Conclusions: Larger sample sizes are required to detect moderate effects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.