Kaposi sarcoma (KS) is a rare angioproliferative disorder, which is usually associated with human herpesvirus-8 infection. Electrochemotherapy (ECT) may be an option in the treatment of KS skin lesions due to the high response rate noted in neoplastic lesions of different histological types. The aim of the present systematic review was to analyse the available evidence on using ECT in the treatment of KS skin lesions. Tumor response, local control and toxicity were analyzed. In the three included studies, the complete response rate was 65-100% and the overall response rate in all studies was 100%. The treatment was well tolerated with mild and transient toxicity. However, further studies are required to fully analyze long-term disease control and to compare ECT with other local therapies used for KS.
Electrochemotherapy in Kaposi sarcoma: A systematic review / Ferioli M.; Galuppi A.; Buwenge M.; Cammelli S.; Perrone A.M.; Macchia G.; Deodato F.; Cilla S.; Zamagni A.; De Terlizzi F.; Tagliaferri L.; De Iaco P.; Morganti A.G.. - In: MOLECULAR AND CLINICAL ONCOLOGY. - ISSN 2049-9450. - STAMPA. - 14:4(2021), pp. 64.1-64.5. [10.3892/mco.2021.2226]
Electrochemotherapy in Kaposi sarcoma: A systematic review
Ferioli M.
;Galuppi A.;Buwenge M.;Cammelli S.;Perrone A. M.;Zamagni A.;De Iaco P.;Morganti A. G.
2021
Abstract
Kaposi sarcoma (KS) is a rare angioproliferative disorder, which is usually associated with human herpesvirus-8 infection. Electrochemotherapy (ECT) may be an option in the treatment of KS skin lesions due to the high response rate noted in neoplastic lesions of different histological types. The aim of the present systematic review was to analyse the available evidence on using ECT in the treatment of KS skin lesions. Tumor response, local control and toxicity were analyzed. In the three included studies, the complete response rate was 65-100% and the overall response rate in all studies was 100%. The treatment was well tolerated with mild and transient toxicity. However, further studies are required to fully analyze long-term disease control and to compare ECT with other local therapies used for KS.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
