A new mild method for protecting alcohols as t-butyl ethers is reported. The reaction proceeds with Mg(ClO4)2 and Boc2O and shows general applicability. The deprotection of t-butyl ethers has also been revisited. Preliminary results indicate the CeCl3â7H2O/NaI system is a very suitable catalyst for their removal.
Unusual and Unexpected Reactivity of t-Butyl Dicarbonate (Boc2O) with Alcohols in the Presence of Magnesium Perchlorate. A New and General Route to t-Butyl Ethers / G. Bartoli; M. Bosco; M. Locatelli; E. Marcantoni; P. Melchiorre; L. Sambri. - In: ORGANIC LETTERS. - ISSN 1523-7060. - STAMPA. - 7:(2005), pp. 427-430. [10.1021/ol047704o]
Unusual and Unexpected Reactivity of t-Butyl Dicarbonate (Boc2O) with Alcohols in the Presence of Magnesium Perchlorate. A New and General Route to t-Butyl Ethers
BARTOLI, GIUSEPPE;BOSCO, MARCELLA;LOCATELLI, MANUELA;MELCHIORRE, PAOLO;SAMBRI, LETIZIA
2005
Abstract
A new mild method for protecting alcohols as t-butyl ethers is reported. The reaction proceeds with Mg(ClO4)2 and Boc2O and shows general applicability. The deprotection of t-butyl ethers has also been revisited. Preliminary results indicate the CeCl3â7H2O/NaI system is a very suitable catalyst for their removal.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
