Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation

Masetti, R.; Biagi, E.; Zama, D.; Muratore, E.; D'Amico, F.; Leardini, D.; Turroni, S.; Prete, A.; Brigidi, P.; Pession, A.

doi:10.1038/s41598-021-93571-4

Hepatic sinusoidal obstruction syndrome (SOS/VOD) represents a dramatic complication of hematopoietic stem cell transplantation (HSCT), particularly in children. Recent evidence has suggested a role for the gut microbiome (GM) in the context of HSCT and its related complications, but no data are available on the relationship between GM and SOS/VOD. Here, we conducted a retrospective case–control study in allo-HSCT pediatric patients developing or not SOS/VOD and profiled their GM over time, from before the transplant up to 72 days after. A rich and diverse GM before HSCT was found to be associated with a reduced likelihood of developing SOS/VOD. Furthermore, prior to transplant, patients not developing SOS/VOD showed an enrichment in some typically health-associated commensals, such as Bacteroides, Ruminococcaceae and Lachnospiraceae. Their levels remained overall higher until post-transplant. This high-diversity configuration resembles that described in other studies for other HSCT-related complications, including graft-versus-host disease, potentially representing a common protective GM feature against HSCT complications.

Titolo:	Early modifications of the gut microbiome in children with hepatic sinusoidal obstruction syndrome after hematopoietic stem cell transplantation
Autore/i:	Masetti R.; Biagi E.; Zama D.; Muratore E.; D'Amico F.; Leardini D.; Turroni S.; Prete A.; Brigidi P.; Pession A.
Autore/i Unibo:	MASETTI, RICCARDO BIAGI, ELENA ZAMA, DANIELE MURATORE, EDOARDO D'AMICO, FEDERICA LEARDINI, DAVIDE TURRONI, SILVIA Prete A. BRIGIDI, PATRIZIA PESSION, ANDREA mostra contributor esterni nascondi contributor esterni
Anno:	2021
Rivista:	SCIENTIFIC REPORTS
Digital Object Identifier (DOI):	http://dx.doi.org/10.1038/s41598-021-93571-4
Abstract:	Hepatic sinusoidal obstruction syndrome (SOS/VOD) represents a dramatic complication of hematopoietic stem cell transplantation (HSCT), particularly in children. Recent evidence has suggested a role for the gut microbiome (GM) in the context of HSCT and its related complications, but no data are available on the relationship between GM and SOS/VOD. Here, we conducted a retrospective case–control study in allo-HSCT pediatric patients developing or not SOS/VOD and profiled their GM over time, from before the transplant up to 72 days after. A rich and diverse GM before HSCT was found to be associated with a reduced likelihood of developing SOS/VOD. Furthermore, prior to transplant, patients not developing SOS/VOD showed an enrichment in some typically health-associated commensals, such as Bacteroides, Ruminococcaceae and Lachnospiraceae. Their levels remained overall higher until post-transplant. This high-diversity configuration resembles that described in other studies for other HSCT-related complications, including graft-versus-host disease, potentially representing a common protective GM feature against HSCT complications.
Data stato definitivo:	2021-09-23T16:22:34Z
Appare nelle tipologie:

File in questo prodotto:

Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

CRIS Current Research Information System

File in questo prodotto: