Repeated but not single administrations of the MAO type B inhibitor (-)-deprenyl (1 μmol/kg s.c. for 21 consecutive days) antagonized the impairment of passive avoidance retention induced by the N-methyl-d-aspartate (NMDA) receptor antagonists 2-amino-5-phosphonovalerate (APV), ketamine and dizocilpine (MK801), in rats. In well-washed membranes prepared from the hippocampi of rats repeatedly treated with (-)-deprenyl, the [3H]MK801 specific binding was increased. In contrast, repeated MAO B-selective doses of pargyline or (+)-amphetamine, as well as single injections with (-)-deprenyl failed to change [3H]MK801 binding. It is suggested that the effects of repeated (-)-deprenyl administrations upon NMDA receptors and upon the impairment of acquisition of a passive avoidance task induced by NMDA antagonists could be independent of MAO inhibition. © 1994.

Repeated administrations of (-)-deprenyl increase [3H]MK801 binding in rat brain and antagonize the impairment of passive avoidance conditioning induced by N-methyl-d-aspartate receptor antagonists

Gandolfi O.
Supervision
;
Dall'Olio R.
Co-primo
Writing – Original Draft Preparation
;
Rimondini R.
Secondo
Investigation
;
1994

Abstract

Repeated but not single administrations of the MAO type B inhibitor (-)-deprenyl (1 μmol/kg s.c. for 21 consecutive days) antagonized the impairment of passive avoidance retention induced by the N-methyl-d-aspartate (NMDA) receptor antagonists 2-amino-5-phosphonovalerate (APV), ketamine and dizocilpine (MK801), in rats. In well-washed membranes prepared from the hippocampi of rats repeatedly treated with (-)-deprenyl, the [3H]MK801 specific binding was increased. In contrast, repeated MAO B-selective doses of pargyline or (+)-amphetamine, as well as single injections with (-)-deprenyl failed to change [3H]MK801 binding. It is suggested that the effects of repeated (-)-deprenyl administrations upon NMDA receptors and upon the impairment of acquisition of a passive avoidance task induced by NMDA antagonists could be independent of MAO inhibition. © 1994.
1994
Gandolfi O.; Dall'Olio R.; Rimondini R.; Bongrani S.; Valsecchi B.
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/826893
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 4
social impact