Dietary modulation of the gastro-intestinal microbiota is a potential target in improving healthy ageing and age-related functional outcomes, including cognitive decline. We explored the association between diet, gastro-intestinal microbiota and cognition in Dutch healthy older adults of the ‘New dietary strategies addressing the specific needs of the elderly population for healthy aging in Europe’ (NU-AGE) study. The microbiota profile of 452 fecal samples from 226 subjects was determined using a 16S ribosomal RNA gene-targeted microarray. Dietary intake was assessed by 7-day food records. Cognitive functioning was measured with an extensive cognitive test battery. We observed a dietary and microbial pro-to anti-inflammatory gradient associated with diets richer in animal-or plant-based foods. Fresh fruits, nuts, seeds and peanuts, red and processed meat and grain products were most strongly associated to microbiota composition. Plant-rich diets containing fresh fruits, nuts, seeds and peanuts were positively correlated with alpha-diversity, various taxa from the Bacteroidetes phylum and anti-inflammatory species, including those related to Faecalibacterium prausnitzii and Eubacterium rectale and E. biforme. Animal product-rich diets associated with pro-inflammatory species, including those related to Ruminococcus gnavus and Collinsella spp.. Cognition was neither associated with microbiota composition nor alpha-diversity. In conclusion, diets richer in animal-and plant-based foods were related to a pro-and anti-inflammatory microbial profile, while cognition was associated with neither.
Associations between pro-and anti-inflammatory gastro-intestinal microbiota, diet, and cognitive functioning in dutch healthy older adults: The nu-age study / van Soest A.P.M.; Hermes G.D.A.; Berendsen A.A.M.; van de Rest O.; Zoetendal E.G.; Fuentes S.; Santoro A.; Franceschi C.; de Groot L.C.P.G.M.; de Vos W.M.. - In: NUTRIENTS. - ISSN 2072-6643. - STAMPA. - 12:11(2020), pp. 3471.1-3471.19. [10.3390/nu12113471]
Associations between pro-and anti-inflammatory gastro-intestinal microbiota, diet, and cognitive functioning in dutch healthy older adults: The nu-age study
Santoro A.Membro del Collaboration Group
;Franceschi C.;
2020
Abstract
Dietary modulation of the gastro-intestinal microbiota is a potential target in improving healthy ageing and age-related functional outcomes, including cognitive decline. We explored the association between diet, gastro-intestinal microbiota and cognition in Dutch healthy older adults of the ‘New dietary strategies addressing the specific needs of the elderly population for healthy aging in Europe’ (NU-AGE) study. The microbiota profile of 452 fecal samples from 226 subjects was determined using a 16S ribosomal RNA gene-targeted microarray. Dietary intake was assessed by 7-day food records. Cognitive functioning was measured with an extensive cognitive test battery. We observed a dietary and microbial pro-to anti-inflammatory gradient associated with diets richer in animal-or plant-based foods. Fresh fruits, nuts, seeds and peanuts, red and processed meat and grain products were most strongly associated to microbiota composition. Plant-rich diets containing fresh fruits, nuts, seeds and peanuts were positively correlated with alpha-diversity, various taxa from the Bacteroidetes phylum and anti-inflammatory species, including those related to Faecalibacterium prausnitzii and Eubacterium rectale and E. biforme. Animal product-rich diets associated with pro-inflammatory species, including those related to Ruminococcus gnavus and Collinsella spp.. Cognition was neither associated with microbiota composition nor alpha-diversity. In conclusion, diets richer in animal-and plant-based foods were related to a pro-and anti-inflammatory microbial profile, while cognition was associated with neither.File | Dimensione | Formato | |
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