We report unprecedented ultra high frequency capacitance spectroscopy measurements up to 500 MHz on a nanoelectrode array for biosensing applications, which extends considerably the previous 70 MHz limit. To achieve this goal, a high-frequency adapter board and measurement system are designed to drive the sensing nanoelectrodes of an existing biochip with appropriate clocks generated by an advanced high-speed pulser. Experimental results in dry and in electrolyte conditions are reported. The extended frequency range enables to overcome the Debye screening cut-off frequency of electrolytes at physiological salt concentrations, thus disclosing new perspectives for single molecule detection.
Ultra-High Frequency (500 MHz) Capacitance Spectroscopy for Nanobiosensing / Cossettini A.; Brandalise D.; Palestri P.; Bertacchini A.; Ramponi M.; Widdershoven F.; Benini L.; Selmi L.. - ELETTRONICO. - 2020-:(2020), pp. 9278583.1-9278583.4. (Intervento presentato al convegno 2020 IEEE Sensors, SENSORS 2020 tenutosi a nld nel 2020) [10.1109/SENSORS47125.2020.9278583].
Ultra-High Frequency (500 MHz) Capacitance Spectroscopy for Nanobiosensing
Benini L.;
2020
Abstract
We report unprecedented ultra high frequency capacitance spectroscopy measurements up to 500 MHz on a nanoelectrode array for biosensing applications, which extends considerably the previous 70 MHz limit. To achieve this goal, a high-frequency adapter board and measurement system are designed to drive the sensing nanoelectrodes of an existing biochip with appropriate clocks generated by an advanced high-speed pulser. Experimental results in dry and in electrolyte conditions are reported. The extended frequency range enables to overcome the Debye screening cut-off frequency of electrolytes at physiological salt concentrations, thus disclosing new perspectives for single molecule detection.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
