OBJECTIVE: To study the effect of stable treatment with sodium oxybate (SO) on nocturnal REM sleep behavior disorder (RBD) and REM sleep without atonia (RSWA) that severely affected children with type 1 narcolepsy (NT1). METHODS: Nineteen children and adolescents with NT1 (9 female, mean age 12.5 ± 2.7 years, mean disease duration 3.4 ± 1.6 years) underwent neurologic investigations and video-polysomnography (v-PSG) at baseline and after 3 months of stable treatment with SO. v-PSG was independently analyzed by 2 sleep experts to rate RBD episodes. RSWA was automatically computed by means of the validated REM sleep atonia index (RAI). RESULTS: Compared to baseline, RAI significantly improved (p < 0.05) and complex movements during REM sleep were remarkably reduced after stable treatment with SO. Compared to baseline, children also reported improvement in clinical complaints and showed a different nighttime sleep-stage architecture. CONCLUSIONS: RBD and RSWA improved after treatment with SO, pointing to a direct role of the drug in modulating motor control during REM sleep. CLASSIFICATION OF EVIDENCE: This study offers Class IV evidence of the positive effect of SO on modulation of muscle atonia during REM sleep in children with NT1 because of the absence of a control group.

REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate / Antelmi E.; Filardi M.; Pizza F.; Vandi S.; Moresco M.; Franceschini C.; Tinazzi M.; Ferri R.; Plazzi G.. - In: NEUROLOGY. - ISSN 1526-632X. - ELETTRONICO. - 96:2(2021), pp. e250-e254. [10.1212/WNL.0000000000011157]

REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate

Filardi M.;Pizza F.;Vandi S.;
2021

Abstract

OBJECTIVE: To study the effect of stable treatment with sodium oxybate (SO) on nocturnal REM sleep behavior disorder (RBD) and REM sleep without atonia (RSWA) that severely affected children with type 1 narcolepsy (NT1). METHODS: Nineteen children and adolescents with NT1 (9 female, mean age 12.5 ± 2.7 years, mean disease duration 3.4 ± 1.6 years) underwent neurologic investigations and video-polysomnography (v-PSG) at baseline and after 3 months of stable treatment with SO. v-PSG was independently analyzed by 2 sleep experts to rate RBD episodes. RSWA was automatically computed by means of the validated REM sleep atonia index (RAI). RESULTS: Compared to baseline, RAI significantly improved (p < 0.05) and complex movements during REM sleep were remarkably reduced after stable treatment with SO. Compared to baseline, children also reported improvement in clinical complaints and showed a different nighttime sleep-stage architecture. CONCLUSIONS: RBD and RSWA improved after treatment with SO, pointing to a direct role of the drug in modulating motor control during REM sleep. CLASSIFICATION OF EVIDENCE: This study offers Class IV evidence of the positive effect of SO on modulation of muscle atonia during REM sleep in children with NT1 because of the absence of a control group.
2021
REM Sleep Behavior Disorder in Children With Type 1 Narcolepsy Treated With Sodium Oxybate / Antelmi E.; Filardi M.; Pizza F.; Vandi S.; Moresco M.; Franceschini C.; Tinazzi M.; Ferri R.; Plazzi G.. - In: NEUROLOGY. - ISSN 1526-632X. - ELETTRONICO. - 96:2(2021), pp. e250-e254. [10.1212/WNL.0000000000011157]
Antelmi E.; Filardi M.; Pizza F.; Vandi S.; Moresco M.; Franceschini C.; Tinazzi M.; Ferri R.; Plazzi G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/793726
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