Ecological sensing and inflammation have evolved to ensure optima between organism survival and reproductive success in different and changing environments. At the molecular level, ecological sensing consists of many types of receptors located in different tissues that orchestrate integrated responses (immune, neuroendocrine systems) to external and internal stimuli. This review describes emerging data on taste and chemosensory receptors, proposing them as broad ecological sensors and providing evidence that taste perception is shaped not only according to sense epitopes from nutrients but also in response to highly diverse external and internal stimuli. We apply a biological anthropological approach to examine how ecological sensing has been shaped by these stimuli through human evolution for complex interkingdom communication between a host and pathological and symbiotic bacteria, focusing on population-specific genetic diversity. We then focus on how these sensory receptors play a major role in inflammatory processes that form the basis of many modern common metabolic diseases such as obesity, type 2 diabetes, and aging. The impacts of human niche construction and cultural evolution in shaping environments are described with emphasis on consequent biological responsiveness.

Ecological Sensing through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach / Giuliani C.; Franceschi C.; Luiselli D.; Garagnani P.; Ulijaszek S.. - In: ADVANCES IN NUTRITION. - ISSN 2161-8313. - ELETTRONICO. - 11:6(2020), pp. 1671-1685. [10.1093/advances/nmaa078]

Ecological Sensing through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach

Giuliani C.
Primo
Conceptualization
;
Franceschi C.;Luiselli D.;Garagnani P.;Ulijaszek S.
Ultimo
Conceptualization
2020

Abstract

Ecological sensing and inflammation have evolved to ensure optima between organism survival and reproductive success in different and changing environments. At the molecular level, ecological sensing consists of many types of receptors located in different tissues that orchestrate integrated responses (immune, neuroendocrine systems) to external and internal stimuli. This review describes emerging data on taste and chemosensory receptors, proposing them as broad ecological sensors and providing evidence that taste perception is shaped not only according to sense epitopes from nutrients but also in response to highly diverse external and internal stimuli. We apply a biological anthropological approach to examine how ecological sensing has been shaped by these stimuli through human evolution for complex interkingdom communication between a host and pathological and symbiotic bacteria, focusing on population-specific genetic diversity. We then focus on how these sensory receptors play a major role in inflammatory processes that form the basis of many modern common metabolic diseases such as obesity, type 2 diabetes, and aging. The impacts of human niche construction and cultural evolution in shaping environments are described with emphasis on consequent biological responsiveness.
2020
Ecological Sensing through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach / Giuliani C.; Franceschi C.; Luiselli D.; Garagnani P.; Ulijaszek S.. - In: ADVANCES IN NUTRITION. - ISSN 2161-8313. - ELETTRONICO. - 11:6(2020), pp. 1671-1685. [10.1093/advances/nmaa078]
Giuliani C.; Franceschi C.; Luiselli D.; Garagnani P.; Ulijaszek S.
File in questo prodotto:
File Dimensione Formato  
Giuliani_Ulijaszek_2020_adv nutrition.pdf

accesso aperto

Tipo: Versione (PDF) editoriale
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND)
Dimensione 2.73 MB
Formato Adobe PDF
2.73 MB Adobe PDF Visualizza/Apri
nmaa078_supplemental_files.zip

accesso aperto

Tipo: File Supplementare
Licenza: Licenza per Accesso Aperto. Creative Commons Attribuzione - Non commerciale - Non opere derivate (CCBYNCND)
Dimensione 102.5 kB
Formato Zip File
102.5 kB Zip File Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/791065
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 2
social impact