The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.
Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis / Sicignano M.; Rodriguez R.I.; Capaccio V.; Borello F.; Cano R.; De Riccardis F.; Bernardi L.; Diaz-Tendero S.; Della Sala G.; Aleman J.. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0539. - ELETTRONICO. - 18:(2020), pp. 2914-2920. [10.1039/d0ob00476f]
Asymmetric trifluoromethylthiolation of azlactones under chiral phase transfer catalysis
Bernardi L.;
2020
Abstract
The first enantioselective method for the installation of the SCF3 group at the C-4 position of azlactones is described in the present communication under quinidinium phase transfer catalysis. The higher performance of substrates containing electron-rich 2-aryl groups at the azlactone was rationalized using DFT calculations.File | Dimensione | Formato | |
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