The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-γ-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.
An Improved Process For The Preparation of Sugammadex Which Involves The Use of a Salt Of 3-mercapto Propionic Acid, Preferably The Di Sodium Salt Of 3-mercapto Propionic Acid / Zanon; J.; Ricci; A.; Lahiri; S.; Cabri W. - (2016).
An Improved Process For The Preparation of Sugammadex Which Involves The Use of a Salt Of 3-mercapto Propionic Acid, Preferably The Di Sodium Salt Of 3-mercapto Propionic Acid
Cabri W
2016
Abstract
The present application provides an improved process for the preparation of sugammadex by reacting a salt of 3-mercapto propionic acid with 6-per-deoxy-6-per-halo-γ-cyclodextrin in a suitable organic solvent. This application also provides crystalline form of a salt of 3-mercapto propionic acid, preferably di sodium salt of 3-mercapto propionic acid and its use for the preparation of sugammadex, whereas formula (I) shows the sodium salt of sugammadex.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
