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EnglishNuclear inositides have a specific subcellular distribution that is linked to specific functions; thus their regulation is fundamental both in health and disease. Emerging evidence shows that alterations in multiple inositide signalling pathways are involved in pathophysiology, not only in cancer but also in other diseases. Here, we give an overview of the main features of inositides in the cell, and we discuss their potential as new molecular therapeutic targets.
| Titolo: | Inositide-Dependent Nuclear Signalling in Health and Disease | |
| Autore/i: | Follo M. Y.; Ratti S.; Manzoli L.; Ramazzotti G.; Faenza I.; Fiume R.; Mongiorgi S.; Suh P. G.; McCubrey J. A.; Cocco L. | |
| Autore/i Unibo: | ||
| Anno: | 2020 | |
| Serie: | ||
| Titolo del libro: | Lipid Signaling in Human Diseases | |
| Pagina iniziale: | 291 | |
| Pagina finale: | 308 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/164_2019_321 | |
| Abstract: | Nuclear inositides have a specific subcellular distribution that is linked to specific functions; thus their regulation is fundamental both in health and disease. Emerging evidence shows that alterations in multiple inositide signalling pathways are involved in pathophysiology, not only in cancer but also in other diseases. Here, we give an overview of the main features of inositides in the cell, and we discuss their potential as new molecular therapeutic targets. | |
| Data stato definitivo: | 2-lug-2020 | |
| Appare nelle tipologie: |
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