The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75-81% overall yield from dihydrolysergic acid 4 with > 99.8% purity.
Development of a practical high-yield industrial synthesis of pergolide mesylate / Cabri W; Roletto J; Olmo S; Fonte P; Ghetti P; Songia S; Mapelli E; Alpegiani M; Paissoni P. - In: ORGANIC PROCESS RESEARCH & DEVELOPMENT. - ISSN 1083-6160. - ELETTRONICO. - 10:2(2006), pp. 198-202. [10.1021/o50501747]
Development of a practical high-yield industrial synthesis of pergolide mesylate
Cabri W;
2006
Abstract
The development of a high-yield and low environmental impact synthesis able to deliver highly pure pergolide mesylate 1 is described. The process [seven chemical steps (four telescoped), three steps of isolation of intermediate, and only one drying] affords pergolide mesylate 1 in 75-81% overall yield from dihydrolysergic acid 4 with > 99.8% purity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
