A systematic study of medicinal chemistry aimed at identifying a new generation of HDAC inhibitors, through the introduction of a thiol zinc-binding group (ZBG) and of an amide-lactam in the ω-position of the polyethylene chain of the vorinostat scaffold
ST7612AA1, a Thioacetate-ω(γ-lactam carboxamide) Derivative Selected from a Novel Generation of Oral HDAC Inhibitors / Giuseppe Giannini*†; Loredana Vesci†; Gianfranco Battistuzzi†; Davide Vignola†; Ferdinando M. Milazzo†; Mario Berardino Guglielmi; Marcella Barbarino; Mosè Santaniello; Nicola Fantò; Marco Mor; Silvia Rivara; Daniele Pala‡p; Maurizio Taddei; Claudio Pisano; Cabri W. - In: JOURNAL OF MEDICINAL CHEMISTRY. - ISSN 0022-2623. - ELETTRONICO. - 57:20(2014), pp. 8358-8377. [10.1021/jm5008209]
ST7612AA1, a Thioacetate-ω(γ-lactam carboxamide) Derivative Selected from a Novel Generation of Oral HDAC Inhibitors
Cabri W
2014
Abstract
A systematic study of medicinal chemistry aimed at identifying a new generation of HDAC inhibitors, through the introduction of a thiol zinc-binding group (ZBG) and of an amide-lactam in the ω-position of the polyethylene chain of the vorinostat scaffoldI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
