Objective: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results: We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.
Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition / Bucci P.; Galderisi S.; Mucci A.; Rossi A.; Rocca P.; Bertolino A.; Aguglia E.; Amore M.; Andriola I.; Bellomo A.; Biondi M.; Cuomo A.; dell'Osso L.; Favaro A.; Gambi F.; Giordano G.M.; Girardi P.; Marchesi C.; Monteleone P.; Montemagni C.; Niolu C.; Oldani L.; Pacitti F.; Pinna F.; Roncone R.; Vita A.; Zeppegno P.; Maj M.; Patriarca S.; Pietrafesa D.; Aiello C.; Longo L.; Barone M.; Romano R.; Atti A.R.; Barlati S.; Deste G.; Valsecchi P.; Carpiniello B.; Tusconi M.; Puddu L.; Signorelli M.S.; Cannavo D.; Minutolo G.; Corbo M.; Montemitro C.; Baroni G.; Altamura M.; La Montagna M.; Carnevale R.; Murri M.B.; Calcagno P.; Bugliani M.; Pizziconi G.; Logozzo F.; Rossi R.; Giusti L.; Salza A.; Malavolta M.; Orsenigo G.; Grassi S.; De Bartolomeis A.; Gramaglia C.; Gattoni E.; Gambaro E.; Tenconi E.; Ferronato L.; Collantoni E.; Tonna M.; Ossola P.; Gerra M.L.; Carmassi C.; Cremone I.M.; Carpita B.; Buzzanca A.; Girardi N.; Frascarelli M.; Del Casale A.; Comparelli A.; Corigliano V.; Siracusano A.; Di Lorenzo G.; Ribolsi M.; Corrivetti G.; Bartoli L.; Del Buono G.; Fagiolini A.; Bolognesi S.; Goracci A.; Mancini I.; Bava I.; Cardillo S.. - In: ACTA PSYCHIATRICA SCANDINAVICA. - ISSN 0001-690X. - STAMPA. - 138:3(2018), pp. 253-266. [10.1111/acps.12938]
Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition
Atti A. R.;
2018
Abstract
Objective: The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method: Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results: We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion: Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
