One of the most important objectives in the science of biomaterials is the development of materials as bone substitutes. Synthetic hydroxyapatite, Ca5OH(PO4)3 (HA), shows very interesting properties, among them, an excellent biocompatibility and bioactive characteristics. For a material to be bioactive, bonds must be formed between its surface and the living bone, such that it becomes covered with an apatite layer. From this initial layer, the osteoblast of living bone can proliferate and produce apatite and collagen, a process termed osteointegration. Recently, it has been shown that glasses of type Na2O-CaO-SiO2 are materials that favour this formation. This is because these materials interchange Na+ and Ca2+ ions with protons in the surrounding fluid which gives rise to Si-OH groups that induce the nucleation of hydroxyapatite. Based on this property of metasilicate matrices, in the diffusive precipitation system used in this work we have obtained pure hydroxyapatite nanocrystals by diffusion of a Ca2+ solution through a silica gel, set with phosphoric acid, at high pH. This new ceramic material has been analysed with a range of experimental techniques (XRD, FT-IR, TGA-DSC, TEM). These nanocrystals have similar dimensions to those of natural bone apatites.

Synthesis of hydroxyapatite nanocrystals in metasilicate gel / IAFISCO M.; B. PALAZZO; G. FALINI; M. MARCHETTI; J. GÓMEZ MORALES; M. A. HERNÁNDEZ-HERNÁNDEZ; J. M. GARCÍA RUIZ; N. ROVERI. - ELETTRONICO. - (2008), pp. 1-1. (Intervento presentato al convegno 2nd International Congress On Ceramics Global Roadmap For Ceramics Icc2 Proceedings. 2nd International Congress on Ceramics, ICC2 tenutosi a Verona nel 29 giugno -4 luglio).

Synthesis of hydroxyapatite nanocrystals in metasilicate gel

IAFISCO, MICHELE;PALAZZO, BARBARA;FALINI, GIUSEPPE;ROVERI, NORBERTO
2008

Abstract

One of the most important objectives in the science of biomaterials is the development of materials as bone substitutes. Synthetic hydroxyapatite, Ca5OH(PO4)3 (HA), shows very interesting properties, among them, an excellent biocompatibility and bioactive characteristics. For a material to be bioactive, bonds must be formed between its surface and the living bone, such that it becomes covered with an apatite layer. From this initial layer, the osteoblast of living bone can proliferate and produce apatite and collagen, a process termed osteointegration. Recently, it has been shown that glasses of type Na2O-CaO-SiO2 are materials that favour this formation. This is because these materials interchange Na+ and Ca2+ ions with protons in the surrounding fluid which gives rise to Si-OH groups that induce the nucleation of hydroxyapatite. Based on this property of metasilicate matrices, in the diffusive precipitation system used in this work we have obtained pure hydroxyapatite nanocrystals by diffusion of a Ca2+ solution through a silica gel, set with phosphoric acid, at high pH. This new ceramic material has been analysed with a range of experimental techniques (XRD, FT-IR, TGA-DSC, TEM). These nanocrystals have similar dimensions to those of natural bone apatites.
2008
2nd International Congress On Ceramics Global Roadmap For Ceramics Icc2 Proceedings. 2nd International Congress on Ceramics, ICC2
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Synthesis of hydroxyapatite nanocrystals in metasilicate gel / IAFISCO M.; B. PALAZZO; G. FALINI; M. MARCHETTI; J. GÓMEZ MORALES; M. A. HERNÁNDEZ-HERNÁNDEZ; J. M. GARCÍA RUIZ; N. ROVERI. - ELETTRONICO. - (2008), pp. 1-1. (Intervento presentato al convegno 2nd International Congress On Ceramics Global Roadmap For Ceramics Icc2 Proceedings. 2nd International Congress on Ceramics, ICC2 tenutosi a Verona nel 29 giugno -4 luglio).
IAFISCO M.; B. PALAZZO; G. FALINI; M. MARCHETTI; J. GÓMEZ MORALES; M. A. HERNÁNDEZ-HERNÁNDEZ; J. M. GARCÍA RUIZ; N. ROVERI
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/73819
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