Increased levels of tear matrix metalloproteinase-9 (MMP-9) have been detected in ocular graft versus host disease (oGVHD) patients. Since MMP-9 is a proteolytic enzyme involved in the degradation of corneal extracellular matrix components, we hypothesized that higher tears levels of MMP-9 might impair corneal biomechanics. Therefore, the purpose of this study was to compare corneal biomechanical properties between patients with oGVHD and healthy matched subjects, and to further correlate these values with ocular surface characteristics.
Ocular Graft Versus-host Disease Patients Exhibit Impaired Corneal Biomechanics / Giannaccare, G; Pellegrini, M; Taroni, L; Bernabei, F; Senni, C; Grendele, A; Moscardelli, F; Arpinati, M; Bonifazi, F; Sessa, M; Versura, P; Campos, EC. - In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. - ISSN 0146-0404. - STAMPA. - 60:9(2019), pp. 6810-6810.
Ocular Graft Versus-host Disease Patients Exhibit Impaired Corneal Biomechanics
Giannaccare, G
;Pellegrini, M;Taroni, L;Bernabei, F;Grendele, A;Moscardelli, F;Sessa, M;Versura, P;Campos, EC
2019
Abstract
Increased levels of tear matrix metalloproteinase-9 (MMP-9) have been detected in ocular graft versus host disease (oGVHD) patients. Since MMP-9 is a proteolytic enzyme involved in the degradation of corneal extracellular matrix components, we hypothesized that higher tears levels of MMP-9 might impair corneal biomechanics. Therefore, the purpose of this study was to compare corneal biomechanical properties between patients with oGVHD and healthy matched subjects, and to further correlate these values with ocular surface characteristics.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
