In this paper, an acetazolamide vibrational study has been conducted to identify its two known polymorphic forms (A and B). Other techniques, such as Hot-stage and X-ray powder diffraction, have been also reported. Moreover, the thermodynamic and spectroscopic behaviour of ground form A has been investigated. In this study, acetazolamide form A was ground at different times (1, 5, 10, 15, 20 min) and FT-IR/ATR and DSC measurements have been carried out. The grinding process, decreasing the particle sizes, has been induced a polymorphic transformation of A to B form. To determine the B in A percentages, calibration curves have been performed by FT-Raman measurements.
Vibrational study of acetazolamide polymorphism / C. Baraldi; M.C. Gamberini; F. Palazzoli; A. Tinti; V. Ferioli. - In: JOURNAL OF MOLECULAR STRUCTURE. - ISSN 0022-2860. - STAMPA. - 918:(2009), pp. 88-96. [10.1016/j.molstruc.2008.07.014]
Vibrational study of acetazolamide polymorphism.
TINTI, ANNA;
2009
Abstract
In this paper, an acetazolamide vibrational study has been conducted to identify its two known polymorphic forms (A and B). Other techniques, such as Hot-stage and X-ray powder diffraction, have been also reported. Moreover, the thermodynamic and spectroscopic behaviour of ground form A has been investigated. In this study, acetazolamide form A was ground at different times (1, 5, 10, 15, 20 min) and FT-IR/ATR and DSC measurements have been carried out. The grinding process, decreasing the particle sizes, has been induced a polymorphic transformation of A to B form. To determine the B in A percentages, calibration curves have been performed by FT-Raman measurements.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
