Ionic cocrystals (ICCs) of LiCl with levodopa and its biological precursors l-tyrosine and l-phenylalanine, namely, l-phe·LiCl·nH2O, l-tyr·LiCl, and l-dopa·LiCl·H2O, were synthesized by mechanochemical mixing of the reactants in the presence of a small quantity of ethanol. In the case of l-dopa, a polymorph of l-dopa·LiCl·H2O was also obtained from solution crystallization. All compounds were investigated by solid state methods, and the structures were determined either from single crystal or from powder diffraction data.
Ionic Cocrystals of Levodopa and Its Biological Precursors l-Tyrosine and l-Phenylalanine with LiCl / Shemchuk O.; Braga D.; Grepioni F.. - In: CRYSTAL GROWTH & DESIGN. - ISSN 1528-7483. - STAMPA. - 19:11(2019), pp. 6560-6565. [10.1021/acs.cgd.9b01003]
Ionic Cocrystals of Levodopa and Its Biological Precursors l-Tyrosine and l-Phenylalanine with LiCl
Shemchuk O.;Braga D.;Grepioni F.
2019
Abstract
Ionic cocrystals (ICCs) of LiCl with levodopa and its biological precursors l-tyrosine and l-phenylalanine, namely, l-phe·LiCl·nH2O, l-tyr·LiCl, and l-dopa·LiCl·H2O, were synthesized by mechanochemical mixing of the reactants in the presence of a small quantity of ethanol. In the case of l-dopa, a polymorph of l-dopa·LiCl·H2O was also obtained from solution crystallization. All compounds were investigated by solid state methods, and the structures were determined either from single crystal or from powder diffraction data.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
